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Methods and compositions for the treatment and repair of defects or lesions in cartilage

  • US 5,368,858 A
  • Filed: 11/23/1992
  • Issued: 11/29/1994
  • Est. Priority Date: 01/31/1991
  • Status: Expired due to Term
First Claim
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1. A composition for the treatment or repair of defects or lesions in cartilage comprising:

  • a biodegradable matrix or matrix-forming material used to dress the area of the defect or lesion in the cartilage;

    a proliferation agent contained within the matrix or matrix-forming material at an appropriate concentration to stimulate the proliferation of repair cells in the matrix and the area of the defect or lesion; and

    a transforming factor associated with a delivery system, the delivery system being contained within the matrix or matrix-forming material, and the transforming factor being present at an appropriate concentration such that upon subsequent delivery of the transforming factor to repair cells in the matrix and defect, the repair cells are transformed into chondrocytes that produce cartilage tissue.

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