Method and apparatus for measuring myocardial impairment, dysfunctions, sufficiency, and insufficiency

• US 5,370,122 A
• Filed: 10/08/1993
• Issued: 12/06/1994
• Est. Priority Date: 11/18/1992
• Status: Expired due to Fees

• Current Assignee: Horst E. Kunig, Sabine V. Kunig
• Original Assignee: Horst E. Kunig, Sabine V. Kunig
• Inventors: Kunig, Sabine V., Kunig, Horst E.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/133,565
• Time in Patent Office: 424 Days
• Field of Search: 128/691-692, 128/694, 128/713, 128/736, 128/670-671, 128/672, 128/668
• US Class Current: 600/483
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

A monitoring device for cardiac efficiency and cardiac sufficiency derived from pre-ejection and post-ejection potentials, cardiac metabolic rate, and cardiac power receives signals representative of ventricular pressures and sizes, body temperature, age, and sex. Cardiac efficiency is determined as the ratio of the mechanical work of the heart performed in one cardiac cycle which is equal to the difference of pre-ejection potential and post-ejection potential to the highest pre-ejection potential. Metabolic rate is determined as a multiple of the minimum cardiac work necessary to sustain life. Cardiac power is determined as the ratio of cardiac work to the time in which this work is performed. Cardiac efficiency and cardiac power are used to determine myocardial impairment, dysfunctions, sufficiency, and insufficiency.

Claims

1. A cardiac diagnostic and monitoring device for an individual including the combination of:

means for obtaining data representative of end-systolic size, end-diastolic size, ventricular systolic blood pressure, and ventricular end diastolic blood pressure;

means responsive to said means for obtaining data for generating electrical signals representative of cardiac ventricular sizes and ventricular pressures of said individual;

means responsive to said electrical signals for producing ventricular pressure-size curves;

means for pre-establishing ventricular pressure-size curves according to a pre-determined reference; and

display means for said ventricular pressure-size curves to allow comparison with said pre-established curves of a pre-determined reference to allow diagnostic monitoring of the individual.

2. The device according to claim 1 further including means for generating electrical signals corresponding to said pre-established ventricular pressure-size curves, said display means being responsive to electrical signals representing ventricular pressure-size curves derived from the ventricular sizes and ventricular pressures of said individual and curves of the pre-determined reference by display in a coordinate frame of reference to allow said comparison.

3. The device according to claim 2 wherein said means for generating electrical signals includes an operating program to construct displays of the ventricular pressure-size curves representing said cardiac ventricular sizes and ventricular pressures and the ventricular pressure-size curves representing said pre-determined reference circumscribe areas within said frame of reference to allow assessment of displaced and incongruent pathological curves indicative of a degree of cardiac dysfunction.

4. The device according to claim 1 wherein said means for producing signals includes a pulmonary artery ejection fraction catheter having a thermistor.

5. The device according to claim 1 wherein said means for producing signals includes a echocardiographic instrumentation.

6. The device according to claim 1 wherein signals representative of body surface normalized values for end-diastolic size and end-systolic size for one cardiac cycle are produced by said means for generating signals.

7. The device according to claim 1 wherein said means responsive to said signals for producing pressure-size curves includes a programmed computer for generating electrical signals corresponding to said preestablished pressure-size curves.

8. A cardiac diagnostic and monitoring device for an individual including the combination of:

means for producing and detecting signals representative of cardiac ventricular sizes and ventricular pressures of said individual;

means responsive to said signals for generating energy level signals representing pre-ejection potentials and post-ejection potentials of said individual;

means for pre-establishing energy levels of pre-ejection and post-ejection potentials of a pre-determined reference; and

display means for said energy level signals representing pre-ejection and post-ejection potentials to allow comparison with said pre-established energy levels of pre-ejection and post-ejection potentials of a pre-determined reference to allow diagnosis and monitoring of the individual.

9. The device according to claim 8 further including means for generating electrical signals corresponding to said pre-established energy levels, said display means including means for display of energy levels representing pre-ejection and post-ejection potentials of said individual and electrical signals corresponding to said pre-established energy levels in an energy reference frame to allow said comparison.

10. The device according to claim 9 wherein said display means includes a display from wherein energy levels representing said pre-ejection potentials and post ejection potentials of said individual and the energy levels representing said pre-determined reference are displayed to allow assessment of energy level differences indicative of a degree of cardiac dysfunction.

11. The device according to claim 8 wherein said means for generating electrical signals uses said pre-established energy levels to generate a basal cardiac metabolic rate signal.

12. The device according to claim 8 wherein said means responsive to said signals generating energy level signals includes a programmed computer for generating electrical signals corresponding to such energy levels.

13. The device according to claim 8 wherein said means for generating energy level signals includes means for generating the cardiac efficiency signal for determining the presence or absense of myocardial impairment or sufficiency.

14. The device according to claim 13 wherein said means for generating energy level signals includes means for generating a signal corresponding to cardiac power for displaying a reference frame for determining a sufficiently compensated or insufficiently compensated dysfunction or life-threatening emergency.

15. The device according to claim 8 wherein said means for generating energy level signals includes means for generating a signal corresponding to maximum cardiac power and contractility for determining myocardial impairment and dysfunction.

16. The device according to claim 8 wherein said means for generating signals is further defined to include generating hemodynamic signals of an individual to establish ventricular pressure-size curves, pre-ejection and post-ejection potentials according to the expressions:

PEP=EDVI * SBP-EDVI * EDP;

POP=ESVI * SBP-ESVI * EDP;

W=PEP-POP;

CF=(PEP-POP)/EDVI * SBP; and

CP=W/RR;

CON=m₁ /(CF+EDP/SBP+ESVI/EDVI-1)

MCP=EDVI * SBP/RR

EDVI=EDV/BSA;

ESVI=ESV/BSA;

where PEP is pre-ejection potential;

EDV is end-diastolic size corresponding to either end-diastolic volume or end-diastolic cross-sectional area;

EDVI is end-diastolic size index;

SBP is systolic pressure;

ESV is end-systolic size corresponding to either end-systolic volume or end-systolic cross-sectional area;

ESVI is end-systolic size index;

EDP is end-diastolic pressure;

POP is post-ejection potential;

W is mechanical heart work;

CF is cardiac efficiency;

CP is cardiac power;

RR is time of one heart beat;

CON is the contractility;

MCP is the maximal cardiac power; and

wherein said display means display signals representing the pressure-size curve, pre-ejection potential/post-ejection potential, work, cardiac efficiency, cardiac power, and the identification of sufficiency, insufficiency, and dysfunctions.

17. The device according to claim 8 wherein said means responsive to said signals generates a signal corresponding to cardiac work for display by said display means.

18. The device according to claim 8 further including means for generating electrical signals corresponding to the predetermined values of cardiac power measured as 1 CMET/sec and exercise and dysfunctions measured as multiples of 1 CMET/sec.

19. The device according to claim 8 further including means for generating a signal representative of time for completion of a cardiac cycle, and wherein said means responsive to said signals responds to said signal representative of time for completion of one cardiac cycle and heart rate signals and said signals representing energy levels for generating a signal representative of cardiac power for display by said display means of cardiac sufficiency and insufficiency.

20. A method of diagnosing cardiac efficiency, metabolic rate and cardiac power comprising the steps of:

providing an individual with detectors responsive to cardiac functions;

generating cardiac ventricular pressure and size signals using said detectors to represent end-diastolic size, end-systolic size, end-diastolic pressure, systolic pressure, of the individual;

using said signals to establish present curves and present pre-ejection and post-ejection potentials of the individual,

determining the curve and an energy level of pre-ejection and post-ejection potentials with cardiac basal metabolic rate, and

comparing the pressure-volume curves and the pre-ejection and post-ejection potentials of the individual with the respective curve and energy levels of the pre-ejection and post-ejection potentials of a pre-determined reference to assess cardiac efficiency.

21. The method according to claim 20 including the further step of using said signals to establish pre-ejection and post-ejection potentials for the individual and using the values for pre-ejection and post-ejection potentials of the individual and pre-established reference values for pre-ejection and post-ejection potentials to establish a measure of cardiac work and cardiac efficiency;

and

providing a signal corresponding to said cardiac work and cardiac efficiency for display.

22. The method according to claim 20 further including the steps of:

establishing a time for completion of one cardiac cycle; and

establishing a measure of cardiac power as a computation using said time for completing of one cardiac cycle and said cardiac ventricular pressure and size; and

establishing a power reference frame scale with multiple numbers of CMET/sec.