Sample measuring device and sample measuring system

• US 5,370,842 A
• Filed: 11/20/1992
• Issued: 12/06/1994
• Est. Priority Date: 11/29/1991
• Status: Expired due to Term

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Miyazaki, Takeshi, Yagi, Takayuki, Tanaka, Kazumi, Ohnishi, Toshikazu, Yoneyama, Yoshito, Isaka, Kazuo, Takayama, Hidehito, Sakuranaga, Masanori, Nishimura, Matsuomi
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): Kim, Christopher Y.
• Application Number:
  US07/979,811
• Time in Patent Office: 746 Days
• Field of Search: 422/82.06, 422/82.05, 422/82.04, 422/81, 422/100, 422/103, 356/410, 356/411, 356/414, 356/440, 250/576, 250/575, 417/213, 417/228
• US Class Current: 422/82.06
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/0636 Focussing flows, e.g. to laminate flows
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2400/0442 thermal energy, e.g. vaporisation, bubble jet
• CPC Class Codes: B01L 2400/0466 Evaporation to induce underpressure
• CPC Class Codes: B01L 3/0268 using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: G01N 15/1459 the analysis being performed on a sample stream
• CPC Class Codes: G01N 15/1484 microstructural devices
• CPC Class Codes: G01N 2035/00237 Handling microquantities of analyte, e.g. microvalves, capillary networks
• CPC Class Codes: G01N 2035/1039 Micropipettes, e.g. microcapillary tubes
• CPC Class Codes: G01N 2035/1041 Ink-jet like dispensers
• CPC Class Codes: G01N 21/0303 Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment G01N21/031 - G01N21/15 take precedence
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 35/08 using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

Abstract

An injection port for injecting a sample, an accumulation portion for accumulating the injected sample having a reagent carrier enclosed, a flow passage portion, having a light receiving element at a measuring position located halfway thereof, for passing a reaction fluid having reacted with the reagent in the accumulation portion therethrough, a micro-pump having a feed action of the sample fluid within the flow passage portion and which is a heat generating element provided near a nozzle downstream of the measuring position of the flow passage portion are formed integrally and intensively as a cartridge by a producing method including a semiconductor fabrication process.

Claims

1. A sample measuring device comprising:

an injection port for injecting a sample liquid;

a flow passage through which said injected sample liquid flows, said flow passage including a measuring portion; and

a micro-pump including a heat generating element provided downstream of said measuring portion of the flow passage for generating a bubble to feed the sample liquid within said flow passage.

2. A sample measuring device according to claim 1, wherein a sensitive element is provided substantially at said measuring portion.

3. A sample measuring device according to claim 2, wherein a plurality of said sensitive elements are provided along a flowing direction in the flow passage.

4. A sample measuring device according to claim 2, wherein said sensitive element comprises a light receiving element and an optical filter that is provided in front of a light receiving surface of said light receiving element.

5. A sample measuring device according to claim 1, wherein an optical functional element having a light condensing action is formed substantially at said measuring position.

6. A sample measuring device according to claim 5, wherein said optical functional element has an action of condensing parallel light flux incident from outside to the measuring portion in the flow passage.

7. A sample measuring device according to claim 1, further comprising an accumulation portion for accumulating said injected sample liquid, wherein a reagent is enclosed in said accumulation portion.

8. A sample measuring device according to claim 7, wherein said reagent contains a biological material.

9. A sample measuring device according to claim 1, further comprising an introduction port for introducing a sheath fluid along with said sample liquid, wherein a sheath flow is formed in said flow passage.

10. A sample measuring device according to claim 1, which comprises a plurality of said flow passages arrayed in parallel relationship to one another.

11. A sample measuring system comprising:

a holding mechanism for holding a cartridge for measurement of a sample liquid;

measuring means for measuring the sample liquid in said cartridge;

wherein said cartridge comprises;

an injection port for injecting a sample liquid;

a flow passage through which said injected sample liquid flows, said flow passage including a measuring portion; and

a micro-pump including a heat generating element provided downstream of said measuring portion of the flow passage for generating a bubble to feed the sample liquid within said flow passage.

12. A sample measuring system according to claim 11, wherein said measuring means includes means for providing a measuring energy to said measuring position.

13. A sample measuring system according to claim 12, wherein said measuring means includes means to measure with optical energy.

14. A sample measuring system according to claim 13, wherein said measuring means comprises a spectroscopic element and a light receiving element.

15. A sample measuring system according to claim 13, wherein a light receiving element for receiving light emitted from said measuring portion is provided inside the cartridge.

16. A sample measuring system according to claim 13, wherein a light receiving element for receiving light emitted from said measuring portion is provided outside the cartridge.

17. A sample measuring system according to claim 13, further comprising means for providing parallel light flux for measurement to said cartridge, wherein said cartridge is provided with an optical functional element for condensing said parallel light to said measuring portion.