Implantable biomedical sensor device, suitable in particular for measuring the concentration of glucose
First Claim
1. An implantable biomedical sensor device for measuring in vivo a presence and/or concentration of physiological substances in an animate body comprising:
- a miniaturized electronic responder responsive to an electromagnetic interrogation field for contactlessly exchanging binary coded information with a transmitter/receiver;
a closed housing of bio-compatible material having qt least one wall, said responder being disposed in said closed housing;
a work electrode having at least a part thereof disposed outside of said housing and comprising a membrane having at least one surface, hollow fibers in said membrane extending transversely to said at least one surface of said membrane and having internal walls and ends thereon, a coating of conductive polymer on said internal walls, and a redox enzyme disposed in said hollow fibers;
a processing device in said housing for receiving signals from said work electrode in operation and converting said signals to binary signals;
electrical connection means between one of said ends of said hollow fibers and said processing device for conducting said signals from said work electrode to said processing device;
a counter-electrode at least a part thereof disposed outside of said housing; and
electrical connection means for connecting said counter-electrode and said processing device.
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Accused Products
Abstract
Implantable biomedical sensor device for measuring in vivo the presence and/or concentration of physiological substances, such as the concentration of glucose, in a human or animal body. A miniaturized electronic responder (1) arranged in a closed housing (2) of biocompatible material in an electromagnetic interrogation field is capable of contactlessly exchanging binary coded information with a transmitter/receiver, and includes electrical connections (4, 5, 6) passed through the wall of the housing, at least a work electrode (10), a counter-electrode (8) and preferably also a reference electrode (9) outside the housing. The work electrode includes a membrane (13) with hollow fibers extending transversely to the surface of the membrane and having internal walls coated with a conductive polymer (15) and in which a redox enzyme (16) is disposed. One end of the hollow fibers is in electrical contact with a processing device (20) which converts the signals supplied by the work electrode in operation to binary signals.
913 Citations
28 Claims
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1. An implantable biomedical sensor device for measuring in vivo a presence and/or concentration of physiological substances in an animate body comprising:
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a miniaturized electronic responder responsive to an electromagnetic interrogation field for contactlessly exchanging binary coded information with a transmitter/receiver; a closed housing of bio-compatible material having qt least one wall, said responder being disposed in said closed housing; a work electrode having at least a part thereof disposed outside of said housing and comprising a membrane having at least one surface, hollow fibers in said membrane extending transversely to said at least one surface of said membrane and having internal walls and ends thereon, a coating of conductive polymer on said internal walls, and a redox enzyme disposed in said hollow fibers; a processing device in said housing for receiving signals from said work electrode in operation and converting said signals to binary signals; electrical connection means between one of said ends of said hollow fibers and said processing device for conducting said signals from said work electrode to said processing device; a counter-electrode at least a part thereof disposed outside of said housing; and electrical connection means for connecting said counter-electrode and said processing device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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10. The implantable sensor device as claimed in claim 29 wherein:
said work electrode further comprises a projecting electrode core, said membrane being mounted on said electrode core.
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25. A system comprising:
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at least one implantable biomedical sensor device as claimed in claim 29; and at least one transmitter/receiver means for generating an electromagnetic interrogation field for activating said at least one sensor device and reading out said sensor device. - View Dependent Claims (26)
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27. A biomedical sensor device for assaying in vitro a presence and/or concentration of physiological substances comprising:
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a miniaturized electronic responder responsive to an electromagnetic interrogation field for contactlessly exchanging binary coded information with a transmitter/receiver; a closed housing of bio-compatible material having at least one wall, said responder being disposed in said closed housing; a work electrode passing through said at least one wall of said housing and comprising an outer part outside of said housing, a membrane having at least one surface, hollow fibers in said membrane extending transversely to said at least one surface of said membrane and having internal walls and ends thereon, a coating of conductive polymer on said internal walls, and a redox enzyme disposed in said hollow fibers; a processing device in said housing for receiving signals from maid work electrode in operation and converting said signals to binary signals; electrical connection means between one of said ends of said hollow fibers and said processing device for conducting said signals from said work electrode to said processing device; a counter-electrode extending through said at least one wall of said housing and having an outer part outside of said housing; and electrical connection means for connecting said counter-electrode end said processing device. - View Dependent Claims (28)
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Specification