Electrodes for iontophoresis

• US 5,374,241 A
• Filed: 04/07/1993
• Issued: 12/20/1994
• Est. Priority Date: 07/21/1989
• Status: Expired due to Term

• Current Assignee: Encore Medical Asset Corporation (Enovis Corp.)
• Original Assignee: Iomed, Inc. (Enovis Corp.)
• Inventors: Petelenz, Tomasz J., Beck, Jon E., Lloyd, Lindsay B., Holt, Clay H., Felman, William F.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/045,040
• Time in Patent Office: 622 Days
• Field of Search: 604/20, 607/149-153
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An improved electrode is disclosed for use in administering drug by means of iontophoresis, comprising a conductive element for receiving an electric current from a current source; a reticulated element having a plurality of reticulum for receiving an ionic drug solution for iontophoretic delivery, the reticulum being loaded or having applied thereto a hydrophilic polymer which is viscous when hydrated; and means for securing the reticulated element to the conductive element so that electric current will be distributed substantially uniformly through the reticulated element when hydrated and when current is delivered to the conductive element. The presently preferred embodiment utilizes open cell polyurethane foam as the reticulated element and high molecular weight polyethylene oxide as the hydrophilic polymer. The reticulum is further loaded with Tween 20, a surfactant, which serves to improve the rate of hydration. A reticulated element formed in accordance with the present invention is pliable and conformable both when in wet or dry state, making an electrode formed in accordance with the present invention susceptible of a wide variety of shapes and sizes and relatively easy to manufacture at reasonably low cost.

Claims

1. An electrode for use in the iontophoretic delivery of an ionic drug comprising:

a conductive element for receiving an electric current delivered from an electric current source;

a reticulated element including a reticulum structure and a plurality of pores formed by said reticulum structure for receiving an ionic drug solution at the time of iontophoretic delivery,

said reticulated element comprising an open cell polyurethane foam having approximately 100 pores per linear inch;

a plurality of the reticulum structure of said reticulated element having applied thereto high molecular weight polyethylene oxide and surfactant; and

means for securing the reticulated element to the conductive element so that electric current will be distributed substantially uniformly through the reticulated element when hydrated and when current is delivered to the conductive element from an electric current source.

2. An electrode as defined in claim 1 further comprising means for rehydrating the reticulated element.

3. An electrode as defined in claim 2, wherein the means for rehydrating the reticulated element comprises a reservoir element for receiving the reticulated element and a solution for hydrating same.

4. An electrode as defined in claim 1 wherein the polyurethane foam of the reticulated element is substantially dry, and hence must be hydrated prior to use in administering drug.

5. An electrode as defined in claim 4, wherein a solution including drug is used to hydrate the reticulated element prior to use.

6. An electrode as defined in claim 4, wherein an ionic form of a drug is dispersed in the dry reticulated element.

7. An electrode as defined in claim 1, wherein the polyethylene oxide comprises in the range of about 10 to about 20 percent of the dry weight of the reticulated element, and the surfactant comprises in the range of about 10 to about 25 percent of the dry weight of the reticulated element.

8. An electrode as defined in claim 1, wherein the polyethylene oxide comprises about 15 percent of the dry weight of the reticulated element, and the surfactant comprises about 17 percent of the dry weight of the reticulated element.

9. An electrode as defined in claim 1, wherein the polyurethane foam of the reticulated element is substantially hydrated with an ionic drug solution so that said electrode need not be hydrated prior to use.

10. An electrode as defined in claim 1, wherein the reticulated element is approximately 2.5 millimeters thick.

11. An electrode as defined in claim 1, wherein the pore size of the reticulated element is in the range of about 60 to about 150 pores per linear inch.

12. An electrode as defined in claim 1, wherein the conductive element comprises a conductive pattern to establish a uniform current density across the face thereof.