Method of delivering a substance to a fallopian tube

• US 5,374,247 A
• Filed: 04/26/1993
• Issued: 12/20/1994
• Est. Priority Date: 10/18/1991
• Status: Expired due to Fees

• Current Assignee: Credit Suisse Incorporated (Credit Suisse)
• Original Assignee: Imagyn Medical Inc. (Imagyn Medical Technologies, Inc.)
• Inventors: Tholin, Keith, Bacich, Steven R., Lowery, Guy R., Woker, Gary M.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): CERMAK, ADAM
• Application Number:
  US08/053,150
• Time in Patent Office: 603 Days
• Field of Search: 604/49-55, 604/271, 604/264, 600/33-35
• US Class Current: 604/515
• CPC Class Codes: A61B 2017/3435 using everted sleeves
• CPC Class Codes: A61M 2025/0018 having a plug, e.g. an inflatable plug for closing catheter lumens
• CPC Class Codes: A61M 25/0119 Eversible catheters

Abstract

A method of delivering a substance to a fallopian tube of a patient which includes obtaining transcervical access to a fallopian tube with an everting catheter. Access to the fallopian tube is obtained by everting an everting element of the everting catheter in the fallopian tube. A substance selected from the group consisting of biological material and cytotoxic agents is then delivered through the everting catheter to the fallopian tube to deposit the substance in the fallopian tube.

Claims

1. A method of delivering a substance to a fallopian tube of a patient comprising:

obtaining transcervical access to a fallopian tube with an everting catheter;

said step of obtaining including everting an everting element of the everting catheter in the fallopian tube; and

delivering a substance selected from the group consisting of biological material and cytotoxic agents through the everting catheter into the fallopian tube to deposit the substance in the fallopian tube.

2. A method as defined in claim 1 wherein the substance is gametes.

3. A method as defined in claim 1 wherein the substance is embryos.

4. A method as defined in claim 1 wherein the substance is a cytotoxic agent.

5. A method as defined in claim 1 including retracting the everting catheter from the fallopian tube leaving the substance in the fallopian tube.

6. A method as defined in claim 1 including providing the substance within the everting catheter prior to the step of obtaining and with the everting element inverted and the step of delivering includes everting the everting element in the fallopian tube sufficiently to deposit the substance in the fallopian tube.

7. A method as defined in claim 1 including inserting an elongated flexible delivery catheter through a substantial length of the everting catheter and carrying out said step of delivering through the delivery catheter.

8. A method as defined in claim 7 including loading the substance into a distal end of the delivery catheter with the delivery catheter extending into the everting catheter and beyond a distal end of the everting catheter.

9. A method as defined in claim 7 including loading the substance into a distal end of the delivery catheter, said step of obtaining includes inserting the everting catheter through the cervix and uterus of a patient to place a distal end of the everting catheter near an ostium of a fallopian tube, and inserting the delivery catheter with the substance loaded therein through said substantial length of the everting catheter following the insertion of the everting catheter through the cervix and uterus.

10. A method as defined in claim 9 wherein the insertion of the delivery catheter is carried out after the step of everting.

11. A method as defined in claim 7 wherein the delivery catheter includes an elongated flexible endoscope extending sufficiently through the everting catheter so it can be used for viewing of the fallopian tube distally of the everting catheter, the method includes viewing the fallopian tube with the endoscope to locate a desired region of the fallopian tube and the step of delivering includes delivering the substance through the delivery catheter to said desired region.

12. A method as defined in claim 11 wherein the endoscope has a working lumen and the step of delivering includes delivering the substance through the working lumen to said desired region.

13. A method as defined in claim 11 wherein the delivery catheter includes an elongated, flexible tube removably coupled to the endoscope and the step of delivering includes delivering the substance through the tube to said desired region.

14. A method as defined in claim 13 including disposing of the tube and sterilizing the endoscope after the step of delivering.

15. A method as defined in claim 7 wherein there is a delivery device coupled to the delivery catheter and including loading the substance into at least one of the delivery device and the delivery catheter prior to said step of delivering.

16. A method as defined in claim 1 including extending an elongated flexible endoscope sufficiently through an everting catheter so it can be used to view the fallopian tube distally of the everting catheter, viewing the fallopian tube with the endoscope to locate a desired region of the fallopian tube and said step of delivering includes depositing the substance at said desired region.

17. A method as defined in claim 16 including withdrawing the endoscope prior to said step of delivering.

18. A method as defined in claim 17 wherein the step of delivering is carried out directly through the everting catheter without a delivery catheter.

19. A method as defined in claim 17 including inserting an elongated delivery catheter through a substantial length of the everting catheter subsequent to the step of withdrawing and carrying out the step of delivering through the delivery catheter.

20. A method of delivering a substance to a fallopian tube of a patient comprising:

inserting an everting catheter which includes an outer catheter having an outer catheter lumen, an inner catheter movable in the outer catheter lumen and having an inner catheter lumen and an everting element coupled to the outer and inner catheters through the cervix and uterus of a patient to a location adjacent an ostium of the fallopian tube;

everting the everting element into the fallopian tube;

providing an endoscope within the inner catheter lumen and within the everting element;

viewing the fallopian tube with the endoscope to locate a desired region of the fallopian;

withdrawing the endoscope; and

delivering a substance selected from the group consisting of biological material and cytotoxic agents through the inner catheter lumen to the fallopian tube to deposit the substance at said desired region.

21. A method as defined in claim 20 including inserting an elongated flexible delivery catheter through a substantial length of the inner catheter lumen subsequent to said step of withdrawing and carrying out said step of delivering through the delivery catheter.

22. A method as defined in claim 20 wherein the desired region is the location of an ectopic pregnancy and said substance is a cytotoxic agent.

23. A method as defined in claim 20 wherein the desired region is a location where it is desired to implant biological material and said substance is biological material.

24. A method as defined in claim 20 wherein the everting element circumscribes a region of the endoscope and is inflatable to grip the endoscope and said step of providing includes introducing a flush solution between the everting element and the endoscope where the everting element grips the endoscope and moving the endoscope relative to the everting element while the flush solution between the everting element and the endoscope.