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Thermo-irreversible gel corneal contact lens formed in situ

  • US 5,376,693 A
  • Filed: 10/26/1990
  • Issued: 12/27/1994
  • Est. Priority Date: 08/07/1990
  • Status: Expired due to Fees
First Claim
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1. A process for forming a protective corneal contact lens in situ comprising administering to a cornea of an eye of a mammal an aqueous composition, wherein said aqueous composition is an aqueous gel having a desired osmolality and pH and comprising(1) an ionic polysaccharide,(2) a surfactant,(3) a polyoxyalkylene polyether having an average molecular weight of about 10,000 to about 100,000, wherein said polyoxyalkylene polyether is selected from the group consisting of(A) polyoxyalkylene polyethers prepared by reacting ethylene oxide and at least one lower alkylene oxide having 3 to 4 carbon atoms with at least one active hydrogen-containing compound having from 3 to 10 carbon atoms and from 3 to 6 active hydrogens to prepare a heteric or block copolymer intermediate and further reacting said copolymer intermediate with at least one alpha-olefin oxide having an average carbon chain length of about 20 to about 45 aliphatic carbon atoms and wherein said alpha-olefin oxide is present in the amount of about 0.3 to 10 percent by weight based upon the total weight of said polyether and(B) polyoxylkylene polyethers prepared by reacting ethylene oxide with at least one active hydrogen-containing compound having from 2 to 10 carbon atoms and from 2 to 6 active hydrogens to prepare a homopolymer intermediate and further reacting said homopolymer intermediate with at least one alpha-olefin oxide having an average carbon chain length of about 20 to 45 aliphatic carbon atoms and wherein said alpha-olefin oxide is present in the amount of about 0.3 to 10 percent by weight based on the total weight of said polyether, and(4) a latent form of a counter-ion capable of thermo-irreversibly cross-linking the ionic polysaccharide.

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