Apparatus for detecting leakage from vascular tissue
First Claim
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1. An apparatus for detecting leakage from vascular tissue located in an anterior region of an eye into aqueous humor, comprising:
- positioning means for maintaining the eye in a generally stationary position,fluorescence exciter light generation means for generating fluorescence exciter light at a fluorescence exciter light wavelength,light conduit means connected to the fluorescence exciter light generation means for directing the fluorescence exciter light onto the aqueous humor,direct light recording means for directly recording fluorescence of the aqueous humor, the direct light recording means being positioned for recording light emitted from a side of the aqueous humor, andbarrier filter means disposed between the eye and the direct light recording means for maximizing passage to the recording means of light having a first wavelength which is the wavelength of light emitted from the aqueous humor, and minimizing passage to the recording means of light having a second wavelength, the second wavelength including the fluorescence exciter light wavelength.
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Abstract
An apparatus and method for directly imaging fluorophores in tissue or fluid. The apparatus includes a fluorescence exciter light source for generating fluorescence exciter light, a collimater for collimating and directing the light onto the material, and a filter between the material and a camera or the examiner'"'"'s eye for passing selected wavelengths of light to the camera or to the examiner'"'"'s eye. The apparatus is useful for detecting leakage in vascular eye tissue, particularly leakage from iris capillaries into surrounding tissues or into the anterior chamber of the eye.
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18 Claims
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1. An apparatus for detecting leakage from vascular tissue located in an anterior region of an eye into aqueous humor, comprising:
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positioning means for maintaining the eye in a generally stationary position, fluorescence exciter light generation means for generating fluorescence exciter light at a fluorescence exciter light wavelength, light conduit means connected to the fluorescence exciter light generation means for directing the fluorescence exciter light onto the aqueous humor, direct light recording means for directly recording fluorescence of the aqueous humor, the direct light recording means being positioned for recording light emitted from a side of the aqueous humor, and barrier filter means disposed between the eye and the direct light recording means for maximizing passage to the recording means of light having a first wavelength which is the wavelength of light emitted from the aqueous humor, and minimizing passage to the recording means of light having a second wavelength, the second wavelength including the fluorescence exciter light wavelength. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for directly visualizing leakage from vascular tissue located in an anterior region of an eye into aqueous humor comprising:
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positioning means for maintaining the eye in a generally stationary position, fluorescence exciter light generation means for generating fluorescence exciter light at a wavelength of 400-500 nm, light conduit means connected to the fluorescence exciter generation means for directing the fluorescence exciter light onto the aqueous humor, and barrier filter means positioned to the side of the eye for maximizing passage of light therethrough which is emitted from the Aqueous humor and has a first wavelength, and minimizing passage of light therethrough having a second wavelength, the second wavelength including the wavelength of the fluorescence exciter light. - View Dependent Claims (15)
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17. An apparatus for detecting leakage of fluorophores from vascular tissue located in an anterior region of an eye into aqueous humor comprising:
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positioning means for maintaining the eye in a generally stationary position fluorescence exciter light generation means comprising a laser for generating fluorescence exciter light at a wavelength of 485-490 nm, light conduit means connected to the fluorescence exciter light generation means for directing the fluorescence exciter light onto the aqueous humor, direct light recording means for directly recording fluorescence of the aqueous humor, the direct light recording means being positioned for recording light emitted from a side of the aqueous humor, and barrier filter means disposed between the eye and the direct light recording means for maximizing passage to the direct light recording means of light having a wavelength greater than or equal to about 500-520 nm, and excluding passage to the direct light recording means of light having wavelength or less than about 500 nm. - View Dependent Claims (16, 18)
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Specification