Selected dose pharmaceutical dispenser

• US 5,378,233 A
• Filed: 11/18/1992
• Issued: 01/03/1995
• Est. Priority Date: 11/18/1992
• Status: Expired due to Fees

• Current Assignee: Habley Medical Technology Corporation
• Original Assignee: Habley Medical Technology Corporation
• Inventors: Foster, Clark B., Smedley, William H., Haber, Terry M.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): CERMAK, ADAM
• Application Number:
  US07/977,754
• Time in Patent Office: 776 Days
• Field of Search: 604/56, 604/68, 604/71, 604/72, 604/82, 604/89, 604/90, 604/83, 604/134, 604/135, 604/152, 604/183, 604/187, 604/189, 604/191, 604/192, 604/207, 604/208, 604/211, 604/220, 604/224 , 604/228, 604/232, 604/236, 604/237, 604/239, 604/246, 604/247, 604/249
• US Class Current: 604/83
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/585 having magnification means, e.g. magnifying glasses
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3148 Means for causing or aiding aspiration or plunger retraction
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Abstract

A dispenser (2) includes a body (4), a needle (110) and one or more hollow cylinders (28) and pistons (144). The needle is movable between predelivery position and a delivery position, at which the inner needle end (112) opens a ball check valve (142) to permit free fluid flow from the cylinder, along a flow path (46) and through the needle. A threaded dose adjuster (164, 166) is mounted within the body and engages a threaded stem (150). The stem is prevented from rotating so that a rotation of the dose adjuster in one direction causes the dose adjuster to move axially away from the piston to compress a drive spring (176) and preload the stem. Moving the needle assembly to the delivery position causes the dose of pressurized pharmaceutical to be automatically driven from the cylinder and through the needle. The cylinder can be refilled by the user through the needle by opening (88, 92, 94) a supplemental pathway (54, 52) and rotating the dose adjuster in the opposite direction.

Claims

1. A liquid pharmaceutical dispenser comprising:

a body;

a needle assembly mountable to the body;

a hollow cylinder and an axially moveable piston within the cylinder, the piston and hollow cylinder defining a pharmaceutical chamber;

user actuated means for fluidly coupling a liquid pharmaceutical within the pharmaceutical chamber to the needle assembly when in an open position and for fluidly sealing the liquid pharmaceutical within the pharmaceutical chamber when in a closed position;

means for selecting a dose of the liquid pharmaceutical to be delivered through the fluidly coupling means and the needle assembly; and

means for automatically driving the piston against the liquid pharmaceutical, thereby driving the piston a distance corresponding to the selected dose, when the user actuated means has been switched from the closed position to the open position, whereby the dose is delivered through the needle assembly.

2. The dispenser of claim 1 wherein the body is sized to accept first and second of the hollow cylinders, dose selecting means and automatically driving means.

3. The dispenser of claim 1 wherein the fluidly coupling means further comprises check valve means for permitting fluid flow from the pharmaceutical chamber while preventing fluid flow into the pharmaceutical chamber.

4. The dispenser of claim 1 wherein the fluidly coupling means includes a flow path coupling the pharmaceutical chamber to the needle assembly.

5. The dispenser of claim 4 further comprising a check valve positioned along the flow path, the check valve configured to permit fluid flow from the pharmaceutical chamber to the flow path but to prevent fluid flow from the flow path into the pharmaceutical chamber.

6. The dispenser of claim 5 wherein the check valve includes a protrusion having a port opening into the pharmaceutical chamber and an elastic band which surrounds the protrusion and covers the port.

7. The dispenser of claim 5 further comprising bypass means for allowing a liquid pharmaceutical to be aspirated into the pharmaceutical chamber while bypassing the check valve.

8. The dispenser of claim 7 wherein the bypass means includes a supplemental pathway fluidly coupling the flow path and the pharmaceutical chamber while bypassing the check valve.

9. The dispenser of claim 8 wherein the bypass means includes aspiration valve means for selectively sealing the supplemental pathway.

10. The dispenser of claim 9 wherein the selectively sealing means includes an aspiration valve means control plate movably mounted to the body near the needle assembly.

11. The dispenser of claim 4 wherein the fluidly coupling means includes a valve element positioned along the flow path.

12. The dispenser of claim 11 wherein the valve element is a check valve.

13. The dispenser of claim 12 wherein the needle assembly includes a double ended needle cannula movably mounted to the body for movement between a predelivery position and a delivery position, and the check valve includes a valve seat and a movable element biased against the valve seat.

14. The dispenser of claim 13 wherein the needle cannula is configured to engage the movable element and move the movable element away from the valve seat when the needle cannula is moved from the predelivery position to the delivery position thereby permitting free flow of fluid from the flow path to the needle cannula.

15. The dispenser of claim 14 wherein the needle cannula is spring biased towards the predelivery position.

16. The dispenser of claim 1 further comprising means for shielding said needle assembly.

17. The dispenser of claim 16 wherein the shielding means includes a shield slidably mounted to the body movable between a safe position covering the needle assembly and a use position exposing the needle assembly.

18. The dispenser of claim 17 further comprising means for temporarily securing the shield in the safe position.

19. The dispenser of claim 1 wherein the dose selecting means includes:

a rotatable dose adjuster having first threads;

a stem having second threads which matingly engage the first threads; and

means for preventing the stem from rotating within the body so that rotation of the dose adjuster causes relative axial movement between the stem and the dose adjuster.

20. The dispenser of claim 19 further comprising means for providing a visual indication of the dose selected.

21. The dispenser of claim 20 wherein the visual indication means includes a rotary display disc mounted within the body and rack and pinion means for threadably coupling the display disc to the dose adjuster so that axial movement of the dose adjuster causes corresponding rotary motion of the display disc.

22. The dispenser of claim 19 wherein the automatically piston driving means includes a compression spring.

23. The dispenser of claim 22 wherein the compression spring is captured between the dose adjuster and the body.

24. The dispenser of claim 1 further comprising means for providing a visual indication of the dose selected.

25. The dispenser of claim 1 wherein the automatically piston driving means includes a compression spring.

26. The dispenser of claim 1 wherein the dose selecting means includes a dose nut and a dose knob telescopingly coupled to one another, the dose knob extending from the body for manual access by the user.

27. A liquid pharmaceutical dispenser comprising:

a body having a body interior, a body proximal end and a body distal end;

a pharmaceutical cartridge, mounted within the body towards the body distal end, including a hollow cylinder having a cartridge interior and a piston movably mounted within the cartridge interior, the piston and hollow cylinder defining a pharmaceutical chamber;

a needle assembly mountable to the body distal end;

means for selectively fluidly coupling the needle assembly to and fluidly sealing the needle assembly from the liquid pharmaceutical in the pharmaceutical chamber when in open and closed positions respectively;

a stem having a distal end coupled to the piston and a proximal end and external stem threads;

a user-rotatable dose adjuster, rotatably mounted within the body, including internal threads engaging the external stem threads so that rotation of the dose adjuster in a first rotary direction tends to drive the threaded stem in a distal direction towards the piston and the dose adjuster in a proximal direction away from the piston, the piston being substantially immovable in the distal direction when the pharmaceutical chamber is filled with a liquid pharmaceutical so that the dose adjuster is forced in the proximal direction;

means for biasing the dose adjuster in the distal direction so that after the dose adjuster has been rotated in the first rotary direction and the dose adjuster has moved in the proximal direction against the force of the biasing means, upon placing the selectively fluidly coupling means in the open position the biasing means forces the dose adjuster and stem therewith in the distal direction thus causing the piston to move in the distal direction forcing at least a portion of the liquid pharmaceutical from the pharmaceutical and the needle assembly is fluidly sealed from the liquid pharmaceutical in the pharmaceutical chamber, through the selectively fluidly coupling means and to the needle assembly.

28. A selected dose, multiple liquid pharmaceutical dispenser comprising:

a body;

a needle assembly mountable to the body;

hollow cylinders and an axially moveable piston within each cylinder, each piston and hollow cylinder defining a variable volume pharmaceutical chamber;

a flow path coupling the pharmaceutical chambers to the needle assembly;

a check valve associated with each of the pharmaceutical chambers and positioned along the flow path, the check valves configured to permit fluid flow from the pharmaceutical chambers into the flow path but to prevent fluid flow from the flow path into the pharmaceutical chambers;

a user actuated delivery valve operably coupling the flow path and the needle assembly, the delivery valve preventing fluid flow from the flow path into the needle assembly when in a closed position and the delivery valve permitting fluid flow from the flow path into the needle assembly when in an open position;

means for selecting a dose of each of the liquid pharmaceuticals to be delivered through the needle assembly; and

means for automatically driving the pistons against the liquid pharmaceuticals within the pharmaceutical chambers, thereby reducing the volumes of the pharmaceutical chambers and driving the pistons distances corresponding to the selected doses, after the dose selecting step and upon switching the delivery valve from the closed position to the open position, whereby the dose of each liquid pharmaceutical is generally simultaneously delivered through the needle assembly.

29. The dispenser of claim 28 further comprising bypass means for allowing a liquid pharmaceutical to be selectively aspirated into each of the pharmaceutical chambers while bypassing the check valves.

30. The dispenser of claim 29 wherein the bypass means includes:

supplemented pathways fluidly coupling the flow path and the pharmaceutical chambers while bypassing the check valves; and

aspiration valve means for selectively sealing the supplemental pathways.

31. The dispenser of claim 28 wherein:

the delivery valve includes a delivery check valve positioned along the flow path, the delivery check valve including a valve seat and a movable element biased against the valve seat; and

the needle assembly includes a double ended needle cannula movably mounted to the body for movement between a predelivery position and a delivery position, the needle cannula being configured to engage the movable element and move the movable element away from the valve seat when the needle cannula is moved from the predelivery position to the delivery position thereby permitting free flow of fluid from the flow path to the needle cannula.

32. The dispenser of claim 28 further comprising:

a shield slidably mounted to the body movable between a safe position covering the needle assembly and a use position exposing at least a portion of the needle assembly; and

means for temporarily securing the shield in the safe position.

33. The dispenser of claim 28 wherein the dose selecting means includes:

rotatable dose adjusters each having first threads;

stems each having second threads which matingly engage the first threads; and

means for preventing the stems from rotating within the body so that rotation of the dose adjusters cause relative axial movement between the stems and the associated dose adjusters.

34. The dispenser of claim 28 further comprising:

a user viewable rotary display disc mounted to the base; and

rack and pinion means for threadably coupling the display disc to the dose selection means so that axial movement of the dose selection means causes corresponding rotary motion of the display disc.

35. A multiple pharmaceutical cartridge-type assembly comprising:

hollow cylinders and an axially moveable piston within each cylinder, each piston and hollow cylinder defining a variable volume pharmaceutical chamber;

a flow path element coupling the hollow cylinders to one another and fluidly coupling the pharmaceutical chambers to an outlet;

a check valve associated with each of the pharmaceutical chambers and positioned along the flow path, the check valves configured to permit fluid flow from the pharmaceutical chambers into the flow path but to prevent fluid flow from the flow path into the pharmaceutical chambers; and

a user actuated delivery valve operably coupling the flow path and the outlet, the delivery valve preventing fluid flow from the flow path into the outlet when in a closed position and the delivery valve permitting fluid flow from the flow path into the outlet when in an open position.

36. The assembly of claim 35 further comprising bypass means for allowing a liquid pharmaceutical to be selectively aspirated into each of the pharmaceutical chambers while bypassing the check valves.

37. The assembly of claim 36 wherein the bypass means includes:

supplemented pathways fluidly coupling the flow path and the pharmaceutical chambers while bypassing the check valves; and

aspiration valve means for selectively sealing the supplemental pathways.