Ion sensor

• US 5,378,344 A
• Filed: 04/07/1993
• Issued: 01/03/1995
• Est. Priority Date: 05/18/1992
• Status: Expired due to Fees

• Current Assignee: Matsushita Electric Industrial Company Limited (Panasonic Holdings Corporation)
• Original Assignee: Matsushita Electric Industrial Company Limited (Panasonic Holdings Corporation)
• Inventors: Nakagawa, Tohru
• Primary Examiner(s): Niebling, John
• Assistant Examiner(s): Bell, Bruce F.
• Application Number:
  US08/043,550
• Time in Patent Office: 636 Days
• Field of Search: 204/403, 204/418, 204/419, 204/416, 204/153.12, 204/153.17, 204/415
• US Class Current: 204/403.07
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions

Abstract

Disclosed is an ion sensor with its electrode covered with a water-repelling organic chemically adsorbed film, which is formed with at least one hole permitting the passage of ions and preventing the passage of biopolymers, thereby accurately measuring ion concentrations over a long period. In forming a silane-based chemically adsorbed monomolecular film on the surface of the electrode, a hole dozens of angstroms in diameter is formed on an organic thin film by physically adsorbing the mask compound and then washing it away. This ion sensor can prevent the passage of macromolecules such as proteins in a living body. The sensor can also be used in a solution containing numerous impurities, and can be applied for monitoring activities in the body by implanting it in a body.

Claims

1. An ion sensor, comprising a thin film formed by fixing water-repelling chemical admolecules to the surface of an electrode via covalent bonding, wherein at least one hole having an area of 0.5-50 nm² is formed in said chemically adsorbed thin film, thereby permitting the passage of ions and preventing the passage of biopolymers.

2. The ion sensor according to claim 1, wherein said chemical admolecules are fixed to the surface of said electrode via covalent bonds comprising siloxane groups (--SiO--).

3. The ion sensor according to claim 1, wherein said chemically adsorbed film is a monomolecular film.

4. The ion sensor according to claim 1 or 3, wherein said chemically adsorbed thin film is formed on an organic siloxane-based inner layer.

5. The ion sensor according to claim 1, 3 or 4, wherein the thickness of said chemically adsorbed thin film is in the range of 1-10 nm.

6. The ion sensor according to claim 1, 3, 4 or 5, wherein the molecules of said chemically adsorbed thin film contain hydrocarbon or fluorocarbon groups.

7. The ion sensor according to claim 1, wherein the biopolymer is a protein.

8. The ion sensor according to claim 1, wherein said electrode is at least one selected from the group consisting of platinum, glassycarbon, silicon, gold and aluminum.

9. The ion sensor according to claim 1, wherein the the thin film is the product of the process comprising:

preparing a chemical adsorbent by dissolving or dispersing chemical admolecules containing water-repelling and chlorosilyl groups and mask molecules with a physical adsorption property in a nonaqueous solution;

dipping and holding an electrode having hydrophilic groups on its surface in said chemical adsorbent;

physically adsorbing the mask molecules to the surface of the electrode;

forming a chemically adsorbed film by a condensation reaction between hydrophilic groups on said electrode surface and the chlorosilyl groups of said chemical admolecules;

washing away the ureacted chemical admolecules and said mask molecules with a nonaqueous solution.

10. The ion sensor according to claim 9, wherein said mask molecule is at least one chosen from the group consisting of carbocyanin or pyridinium compounds having molecular weights in the range of 500-1000.