Non-invasive determination of analyte concentration in body of mammals
DCFirst Claim
1. A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising the steps of:
- (a) projecting near infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths;
(b) sensing the resulting radiation emitted from said portion of the body;
(c) deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation;
(d) pretreating said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength; and
(e) performing multivariate analysis of said second expression to obtain a value for the concentration of said analyte.
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Abstract
A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, includes the steps of projecting near-infrared radiation on a portion of the body of the mammal, the radiation including a plurality of wavelengths; sensing the resulting radiation emitted from the portion of the body; deriving from the sensed resulting radiation emitted from the portion of the body a first expression for the magnitude of the sensed radiation as a function of wavelength of the sensed radiation; pretreating the first expression to minimize the influence of offset and drift to obtain a second expression for the magnitude of the sensed radiation as a function of wavelength; and performing multivariate analysis of the second expression to obtain a value for the concentration of the analyte.
307 Citations
8 Claims
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1. A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising the steps of:
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(a) projecting near infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) sensing the resulting radiation emitted from said portion of the body; (c) deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; (d) pretreating said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength; and (e) performing multivariate analysis of said second expression to obtain a value for the concentration of said analyte. - View Dependent Claims (2, 3, 4)
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5. An apparatus for non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising:
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(a) means for projecting near-infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) means for sensing the resulting radiation emitted from said portion of the body; (c) means for deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; and (d) data processing means adapted to (i) pretreat said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength and (ii) perform multivariate analysis of said second expression to obtain a value for the concentration of said analyte. - View Dependent Claims (6, 7, 8)
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Specification