Method and apparatus for transcranial doppler sonography

• US 5,379,770 A
• Filed: 12/21/1993
• Issued: 01/10/1995
• Est. Priority Date: 12/21/1993
• Status: Expired due to Term

• Current Assignee: CareFusion 209, Inc.
• Original Assignee: Nicolet Biomedical, Inc. (Thermo Fisher Scientific Incorporated)
• Inventors: Van Veen, Barry D.
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/172,594
• Time in Patent Office: 385 Days
• Field of Search: 128/661.07-661.10, 73/861.25, 364/413.25
• US Class Current: 600/455
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: G01S 15/58 Velocity or trajectory determination systems; Sense-of-movement determination systems velocity measurement in imaging systems G01S15/8979

Abstract

The effect of noise in the displayed information obtained from transcranial Doppler measurements is reduced by estimating the spectra of the returned Doppler signal as the average of Fourier spectra computed using multiple windows for the data being analyzed. The windows are chosen so that the spectra from different windows are approximately statistically independent, thereby reducing the variance of the spectrum by the averaging process. The Doppler data may be obtained by applying repeated pulses of ultrasonic energy to the head of a subject and isolating the Doppler frequency components of the return signal to obtain a set of data from a selected number of pulses. The data set so obtained has the multiple window functions applied thereto to obtain multiple windowed data sets which are operated on, as in a digital signal processor, to obtain multiple discrete Fourier transforms of the windowed data sets. A power spectrum is estimated as the averaged sum of the squares of the magnitudes of each of the discrete Fourier transforms. The spectra obtained from data sets gathered in sequence may be displayed to an operator to show the spectral content of the return signal over time, which corresponds to the velocity of blood flow at a position within the head of the subject as a function of time.

Claims

1. A method for carrying out Doppler sonography on a subject comprising the steps of:

(a) applying a pulse of ultrasound to the subject;

(b) measuring the received ultrasound signal and providing a corresponding received electrical signal;

(c) isolating the Doppler frequency components from the received signal;

(d) sampling the isolated Doppler frequency components to provide digital data corresponding to the sample;

(e) repeating the foregoing steps to provide a set of data for a selected number of samples;

(f) determining a power spectrum for the data set by providing multiple window functions for the data set, the window functions determined so that the spectra computed using different windows are approximately statistically independent, applying each of the window functions to the data set to provide windowed data sets and determining a discrete Fourier transform for each of the windowed data sets, and determining the power spectrum as the averaged sum of the squares of the magnitudes of each of the discrete Fourier transforms of the windowed data sets;

(g) repeating the foregoing steps to provide a power spectra as a function of time.

2. The method of claim 1 including the step of displaying to an operator the power spectra as a function of time.

3. The method of claim 1 wherein the step of determining the power spectrum S_MW (f) as a function of the discrete frequency f is carried out by evaluating the expression:

##EQU7## where M is the number of window functions applied to the data sets, v_j (k) is the k th element of the j th window function, x(k) is the k th element of the data set, k=0, 1, 2, . . . , N-1, and N is the number of samples in the data set.

4. The method of claim 3 wherein the step of providing multiple window functions for the data set provides window functions which are the eigenvectors v_j of the matrix Q having entries Q_mm determined as follows:

##EQU8## where B is a selected number.

5. The method of claim 4 wherein B is a number from 2/N to 8/N.

6. The method of claim 3 wherein the step of providing multiple window functions for the data set provides window functions which are the eigenvectors v_j of the matrix T having entries determined as follows:

##EQU9## where B is a selected number.

7. The method of claim 6 wherein B is a number from 2/N to 8/N.

8. Apparatus for Doppler sonography comprising:

(a) an ultrasound transducer for providing ultrasound pulses to a subject and for receiving ultrasound echoes from the subject and providing a received signal corresponding thereto;

(b) an ultrasound signal generator generating pulses of electrical signal at an ultrasound frequency connected to provide such pulses to the ultrasound transducer;

(c) means connected to the ultrasound transducer for isolating the Doppler frequency components from the received signal from the ultrasound transducer;

(d) an analog-to-digital converter connected to the means for isolating the Doppler frequency components to convert the components to digital data corresponding to the sample;

(e) digital processing means for receiving the digital data corresponding to the samples from the analog-to-digital converter and for determining a power spectrum for the data set obtained from a selected number of samples comprising a data set corresponding to a selected number of pulses of ultrasound provided to a subject including means for providing multiple window functions for the data set, the window functions determined so that the spectra computed using different windows are approximately statistically independent, means for applying each of the window functions to the data set to provide windowed data sets and for determining a discrete Fourier transform for each of the windowed data sets, and for determining the power spectrum as the averaged sum of the squares of the magnitudes of each of the discrete Fourier transforms of the windowed data sets, and for determining the power spectrum for new sets of data corresponding to a selected number of samples over a period of time to provide a power spectra as a function of time.

9. The apparatus of claim 8 including means for displaying to an operator the power spectra as a function of time.

10. The apparatus of claim 8 wherein the means for determining the power spectrum S_MW (f) as a function of the discrete frequency f does so by evaluating the expression:

##EQU10## where M is the number of window functions applied to the data sets, v_j (k) is the k th element of the j th window function, x(k) is the k th element of the data set, k=0, 1, 2, . . . , N-1, and N is the number of samples in the data set.

11. The apparatus of claim 10 wherein the means for providing multiple window functions for the data set provides window functions which are the eigenvectors v_j of the matrix Q having entries Q_mm determined as follows:

##EQU11## where B is a selected number.

12. The apparatus of claim 11 wherein B is a number from 2/N to 8/N.

13. The apparatus of claim 12 wherein the means for providing multiple window functions for the data set provides window functions which are the eigenvectors v_j of the matrix T having entries determined as follows:

##EQU12## where B is a selected number.