Measurement of arterial elasticity and the frequency characteristic of the compliance of an artery

• US 5,379,774 A
• Filed: 03/25/1994
• Issued: 01/10/1995
• Est. Priority Date: 10/23/1990
• Status: Expired due to Fees

• Current Assignee: Sankyo Company Limited (Daiichi Sankyo Company Limited)
• Original Assignee: Sankyo Company Limited (Daiichi Sankyo Company Limited)
• Inventors: Orihashi, Yasushi, Takahashi, Masaaki, Nishimura, Masatoshi
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/218,022
• Time in Patent Office: 291 Days
• Field of Search: 128/633-634, 128/664-667, 128/672, 128/677-683, 128/687-690, 128/691, 128/694, 128/713
• US Class Current: 600/479
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02422 within occluders
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

An apparatus for measuring arterial elasticity includes a cuff member having a light source and light detector, a variable pressure generating device, a fluid pressure sensor, a digital signal processor and a difference detecting element. The fluid pressure in a fluid pressure chamber in the cuff member is varied by a variable fluid pressure generating device. The digital signal processor responds to the output of the fluid pressure sensor and the output of the difference detecting element and delivers a digitally processed signal corresponding to an arterial volume change based on a simulated arterial elasticity. The arterial elasticity and the frequency characteristic thereof are derived based on the operation of the digital signal processor.

Claims

1. An apparatus for measuring arterial elasticity and the frequency characteristic of the compliance of an artery to determine the degree of sclerosis of the artery, comprising:

a cuff member having therein a light source and a light detector for accommodating an object to be measured and for transmitting a light through the object;

light source drive means connected to said light source for driving said light source;

a variable fluid pressure generating means connected to a fluid pressure chamber in said cuff member for supplying a varying fluid pressure in the form of random noise to said fluid pressure chamber;

a fluid passage connected to said fluid pressure chamber;

a fluid pressure sensor means, coupled to said fluid passage, for detecting the varying fluid pressure in the form of random noise in said fluid passage, the fluid pressure sensor means providing an output indicative of the detected pressure;

a digital signal processor means, responsive to a signal corresponding to the output of said fluid pressure sensor means and responsive to a further signal, for delivering a digitally processed signal corresponding to an arterial volume change based on a simulated arterial elasticity; and

a difference detecting means, responsive to one input signal corresponding to an output of said light detector and another input signal corresponding to the digitally processed output signal of said digital signal processor means, for producing a signal which represents the difference between the two input signals and which is supplied to said digital signal processor means as the further signal;

arterial elasticity and the frequency characteristic of the compliance of the artery being derived based on the operation of said digital signal processor means to determine the degree of sclerosis of the artery.

2. An apparatus according to claim 1, wherein said digital signal processor means and said difference detecting means operate as an adaptive filter.

3. An apparatus according to claim 1, wherein said digital signal processor means and said difference detecting means process a system identification.

4. An apparatus according to claim 1, wherein said digital signal processor means and said difference detecting means calculate an error value, using transfer functions of arterial elasticity, a simulated transfer function of arterial elasticity, and summing elements.

5. A method for measuring arterial elasticity and the frequency characteristic of the compliance of an artery in a finger to determine the degree of sclerosis of the artery, comprising the steps of;

varying fluid pressure in a cuff member applied to the finger as an object to be measured, including varying the fluid pressure in the form of random noise;

receiving, by a light detector, a light emitted from a light source in the cuff member and transmitted through the finger to which the fluid pressure in the cuff member is applied, and measuring the transmitted light intensity; and

carrying out an adaptive signal processing by a digital signal processor based on fluid pressure data representing the fluid pressure in the cuff member and the transmitted light data representing the intensity of the light transmitted through the finger;

wherein said method measures arterial elasticity of the finger and the frequency characteristic of the compliance of the artery in the finger to determine the degree of sclerosis of the artery eliminating a correlation between the fluid pressure in the cuff member and an arterial volume change due to an arterial internal blood pressure.

6. An apparatus for measuring arterial elasticity, comprising:

a cuff for receiving a body member, the cuff having a light source, a light detector which generates a light detector signal, and a fluid pressure chamber;

variable pressure generating means for supplying fluid pressure which varies in a non-periodic manner to the fluid pressure chamber;

means for generating a pressure signal which is indicative of the fluid pressure in the fluid pressure chamber; and

means for determining the arterial elasticity in response to the light detector signal and the fluid pressure signal, the means for determining including

a digital signal processor which receives first and second input signals and which generates an output signal, the first input signal corresponding to the pressure signal, and

means for generating a difference signal which represents the difference between the output signal of the digital signal processor and a signal which corresponds to the light detector signal, the difference signal serving as the second input signal to the digital signal processor.

7. The apparatus of claim 6, wherein the variable pressure generating means comprises a conduit connected to the fluid pressure chamber, means for supplying a flow of air to the conduit, a servo valve connected to the conduit to selectively release air from the conduit, means for generating a non-repeating sequence of numbers, and means for controlling the servo valve in response to the non-repeating sequence of numbers.

8. The apparatus of claim 7, wherein the means for generating a non-repeating sequence of numbers comprises a register and an exclusive-OR gate connected to the register.

9. The apparatus of claim 6, wherein the digital signal processor and the means for generating a difference signal comprise an adaptive filter.

10. The apparatus of claim 6, wherein the digital signal processor and the means for generating a difference signal process a system identification.

11. The apparatus of claim 6, wherein the digital signal processor comprises a digital signal processor IC.