Biocompatible microcapsules
First Claim
1. A method for producing transplantable microcapsules wherein the surface is resistant to cellular attachment comprising forming an outer layer of non-ionic water soluble polymers having molecular weights between 2,000 and 100,000 daltons which have been covalently grafted to at least one of the layers, made of polyamine or polyimine polycationic polymers, of the microcapsule membrane, such that said polycationic polymers remain polycationic after grafting.
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Abstract
Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of the microcapsules.
510 Citations
21 Claims
- 1. A method for producing transplantable microcapsules wherein the surface is resistant to cellular attachment comprising forming an outer layer of non-ionic water soluble polymers having molecular weights between 2,000 and 100,000 daltons which have been covalently grafted to at least one of the layers, made of polyamine or polyimine polycationic polymers, of the microcapsule membrane, such that said polycationic polymers remain polycationic after grafting.
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5. A method for making microcapsules comprising using, as an outer layer, non-ionic water soluble polymers having molecular weights between 2,000 and 100,000 daltons that are stable in a biological environment covalently grafted to at least one of the layers of the microcapsule membrane made of polyamine or polyimine polycationic polymers to create a graft copolymer, wherein the grafting comprises the steps of:
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a) activating the free reactive groups capable of being covalently linked, to a coupling agent on the water soluble non-ionic polymers, and b) coupling the activated water soluble non-ionic polymers to the polycationic polymers; and wherein the resulting graft copolymer retains a polycationic charge. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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21. A method for producing transplantable microcapsules wherein a non-ionic water soluble layer surrounds the microcapsules, comprising covalently grafting water soluble non-ionic polymers having molecular weights between 2,000 and 100,000 daltons to polyamine or polyimine polycationic polypeptides to create a graft copolymer and using said graft copolymer as a layer of the microcapsules.
Specification