Ventilator control system for mixing and delivery of gas

• US 5,383,449 A
• Filed: 09/28/1993
• Issued: 01/24/1995
• Est. Priority Date: 06/22/1989
• Status: Expired due to Term

• Current Assignee: Puritan Bennett Corp. (Medtronic Plc)
• Original Assignee: Puritan Bennett Corp. (Medtronic Plc)
• Inventors: Forare, Lester, Gagne, Roger, Fennema, Paul
• Primary Examiner(s): Asher, Kimberly L.
• Application Number:
  US08/128,546
• Time in Patent Office: 483 Days
• Field of Search: 128/204.21, 128/204.22, 128/205.11, 128/205.13-205.17, 128/204.28, 128/205.24
• US Class Current: 128/205.11
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 16/204 used for inhalation control
• CPC Class Codes: A61M 16/205 used for exhalation control
• CPC Class Codes: A61M 16/209 Relief valves
• CPC Class Codes: A61M 2016/0027 pressure meter

Abstract

The ventilator control system for delivery respiratory gas to a patient involves an apparatus which includes a pressure sensor for measuring the pressure within a gas containment vessel, the control of the flow of respiratory gas into the containment vessel responsive to pressure within the containment vessel, and the control of the outflow of respiratory gas responsive to changes in pressure in the containment vessel. Both the inflow of gas to a receiver tank and outflow of respiratory gas are responsive to modes of breathing being provided to a patient.

Claims

1. A ventilator system for the intermittent delivery of respiratory gas to a patient comprising:

a rigid, fixed wall pressure containment vessel;

first and second inlet ports connected to said vessel, with each said inlet, port being in fluid communication with corresponding first and second separate sources of first and second respective component gases to be combined in a desired ratio to form said respiratory gas, said component gases having an initial known ratio, with said first and second inlet ports having associated corresponding first and second inlet valves for individually controlling the flow of each said component gas through said inlet ports to said vessel;

outlet means to connect said vessel in fluid communication with the patient;

sensor means to determine onset and completion of inhalation by the patient, to sense the pressure of said respiratory gas in the containment vessel following said completion of inhalation by of the patient, and to generate a differentiated pressure signal representing a rate of change of pressure in said containment vessel over a period of time;

inlet flow control means to sequentially control the flow of said first component gas into said containment vessel in response to said determination of completion of inhalation by the patient through said first inlet port while said second inlet port is closed, and to control the flow of said second component gas through said second inlet port while said first inlet port is closed, in a desired ratio responsive to the pressure of gas sensed in the containment vessel, including means for determining a desired pressure change value for each said component gas in said containment vessel corresponding to the number of moles of each said component gas required to fill said vessel with said desired ratio of said component gases to a desired fill pressure based upon a total pressure and said initial known ratio of component gases in said vessel, and means for determining an actual ratio of said component gases in said respiratory gas in said vessel based upon sensed changes in pressure of said component gases introduced into said containment vessel; and

outlet flow control means electrically connected to said sensor means to control the flow of said respiratory gas through the outlet means following said onset of inhalation in a predetermined manner responsive to said differentiated pressure signal based upon the rate of change in the pressure of gas sensed in the containment vessel.

2. The system of claim 1, wherein said outlet flow control means comprises means for determining the rate of outflow of said respiratory gas from said vessel responsive to said differentiated pressure signal from said sensor means, output comparison means for comparing said rate of outflow with a predetermined reference outflow value adapted to generate an error signal, and valve means in fluid communication with said outlet means operatively connected to said output comparator means to receive said error signal, and adapted to adjust said outflow to said predetermined outflow value in response to said signal.

3. The system of claim 1, wherein said inlet flow control means includes fill control means for comparing the pressure of gas in said vessel with a predetermined threshold pressure, responsive to said pressure of gas sensed by said sensor means, and adapted to generate a fill signal when the pressure of gas in said vessel falls below said threshold pressure valve, said first and second inlet valves being operatively connected to said fill control means for receiving said fill signal.

4. The system of claim 1, wherein said inlet flow control means includes means for determining a predicted pressure of gas in said vessel after a predicted next inhalation by the patient, based upon said sensed rate of change of pressure in said vessel, and fill control means for comparing said predicted pressure of gas with a predetermined pressure threshold value.

5. A method for intermittently delivering respiratory gas to a patient from a respirator by providing a rigid, fixed wall pressure containment vessel having first and second inlet ports, each of said inlet ports connecting the vessel in fluid communication with first and second separate sources of respective first and second component gases to be combined in said vessel in a desired ratio to form said respiratory gas, said respiratory gas in said vessel having an initial known ratio of said component gases;

providing outlet means to connect the vessel in fluid communication with the patient;

providing sensor means to sense the pressure of said respiratory gas in the containment vessel; and

providing means to sequentially control the flow of said component gases through said inlet ports; and

output flow control means to control the flow of said respiratory gas through said outlet means, said method further comprising the steps of;

determining onset and completion of inhalation by the patient;

measuring the pressure of gas within said vessel following said completion of inhalation by the patient;

determining pressure increase values for said first and second component gases in said vessel corresponding to the number of molecules of each said component gas required to fill said vessel with said desired ratio of said component gases to a desired fill pressure based upon the total pressure and said initial known ratio of component gases in said vessel;

sequentially filling said vessel with said component gases to said corresponding pressure increase values while measuring pressure in said containment vessel in response to said determination of completion of inhalation by the patient, by introducing said first component gas into said vessel through said first inlet port while said second inlet port is closed, and said second component gas through said second inlet port while said first inlet is closed according to said pressure change values until said fill pressure of gas in said vessel is reached;

measuring an actual pressure increase in said containment vessel for each said component gas introduced into said vessel;

determining the ratio of said component gases in said containment vessel based upon said initial known ratio of component gases in said vessel, said total pressure and said actual pressure changes for each said component gas introduced into said vessel;

withdrawing said gas from said vessel through said outlet means responsive to said determination of onset of inhalation;

measuring an outflow rate of change in the pressure of gas in the vessel over time and generating a differentiated pressure signal representing the outflow rate of change of pressure in said vessel over said period of time; and

controlling said withdrawing of gas from said vessel in a predetermined manner responsive to said outflow rate of change in the pressure of gas sensed in said containment vessel.

6. The method of claim 5 wherein said step of controlling said withdrawing of gas comprises comparing said rate of change in the pressure of gas with a predetermined reference outflow value and generating an error signal representing the difference between said rate of change in the pressure of gas and said reference outflow value;

and

adjusting said outflow in said outlet in response to said error signal to reduce the difference between said rate of change in the pressure of gas and said reference outflow value.

7. The method of claim 5, further including the steps of:

comparing said measured pressure of gas in said vessel with a predetermined threshold value; and

introducing said first and second component gases into said vessel in said desired ratio when the pressure in said vessel falls below said threshold value and until the total pressure of said gas in said vessel reaches a predetermined upper limit.

8. The method of claim 5, further including the steps of:

determining a predicted pressure in said vessel after a predicted next inhalation of the patient based upon said sensed rate of change in pressure in said vessel over a predetermined period of time;

comparing said predicted pressure with a predetermined threshold pressure value; and

filling said vessel with said gas when said predicted pressure falls below said predetermined threshold pressure value.