Method, apparatus and procedure for non-invasive monitoring blood glucose by measuring the polarization ratio of blood luminescence
First Claim
1. A method of determining blood glucose concentration from non-invasive measurements of a state of polarization of light emitted by a luminescing center of blood which are dissolved and/or attached to optically active molecules of sugar and upon interaction rotate the initial polarization comprising:
- a. illuminating sample tissue with a beam with linearly or circularly polarized light,b. said light having a wavelength absorbed by blood constituents,c. detecting emitted luminescence light from the tissue at a predetermined emission wavelength,d. analyzing the state of polarization of said emitted light,e. correlating the state of emitted light polarization with blood glucose concentration.
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Abstract
A method, apparatus and procedure for the non-invasive detection of the sugar concentration changes in body liquids such as blood is disclosed. The instrument measures sugar concentration changes using the natural fingerprint of sugar which is rotations of polarization of light emitted from the biological particle chromophores dissolved together with sugar in human liquids. The degree of polarization of light emitted from luminescence centers undergoing interaction with an optically active medium such as sugar is proportional to the concentration of sugar in, for example, blood. The reference level is determined by conventional blood analysis using standard monitoring equipment during the special procedure of the Glucose Tolerance Test.
183 Citations
8 Claims
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1. A method of determining blood glucose concentration from non-invasive measurements of a state of polarization of light emitted by a luminescing center of blood which are dissolved and/or attached to optically active molecules of sugar and upon interaction rotate the initial polarization comprising:
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a. illuminating sample tissue with a beam with linearly or circularly polarized light, b. said light having a wavelength absorbed by blood constituents, c. detecting emitted luminescence light from the tissue at a predetermined emission wavelength, d. analyzing the state of polarization of said emitted light, e. correlating the state of emitted light polarization with blood glucose concentration.
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2. An instrument for non-invasive blood glucose measurements based on a state of polarization of native luminescence from blood comprising:
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a. means for illuminating a blood carrying tissue with a beam of monochromatic, polarized light, and causing the blood in said tissue to emit native luminescence light, b. means for detecting said emitted native luminescence light from the blood at a predetermined wavelength, c. means for detecting the state of polarization of the emitted native luminescence light from the blood, and d. means for correlating the polarization state of the emitted native luminescence light from said blood with blood glucose concentration. - View Dependent Claims (3, 4, 5, 6, 7, 8)
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Specification