Guidewire catheter and apparatus for diagnostic imaging

• US 5,383,467 A
• Filed: 11/18/1992
• Issued: 01/24/1995
• Est. Priority Date: 11/18/1992
• Status: Expired due to Term

• Current Assignee: SpectraScience, Inc.
• Original Assignee: SpectraScience, Inc.
• Inventors: Chornenky, Victor I., Fettig, Peter T., Auer, Michael L., Gunderson, Richard C., McBroom, Jeffrey A., Sharrow, James S.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Casler, Brian L.
• Application Number:
  US07/977,985
• Time in Patent Office: 797 Days
• Field of Search: 128/664, 128/665, 128/656-658, 128/772, 128/633, 128/634, 604/280, 604/282, 606/3, 606/15, 250/227.19, 356/345
• US Class Current: 600/342
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/6851 Guide wires

Abstract

A catheter comprising a unitary guidewire and single mode optical fiber is used to illuminate human body channels, such as a tissue mass within a blood vessel, for purposes of diagnosis. A low coherent light source illuminates the tissue and provides a reference beam. Illumination that is reflected from the tissue is combined with the reference beam in an interferometer process. The path length of the reference beam is changed in a known manner in order to provide a known reference to the distance inside of the tissue from which reflected radiation is being received, thus providing information as to both the nature and the geometry of the tissue. A high signal to noise ratio is provided.

Claims

1. Tissue diagnostic apparatus comprising;

a guidewire/optical fiber catheter having a proximal end and a distal end, and having elongated guidewire means for serving as a guide wire and elongated light conducting optical fiber means for illuminating tissue that is adjacent to the distal end of said guidewire/optical fiber catheter, to thereby produce reflected illumination from the tissue,

a low coherent source of illumination adjacent the proximal end of said guidewire/optical fiber catheter,

beam splitting means intermediate said source of illumination and the proximal end of said guidewire/optical fiber catheter,

said beam splitting means operating to provide a first beam path that extends into the proximal end of said guidewire/optical fiber catheter, and operating to provide a second beam path extending from said beam splitting means,

said beam splitting means also operating to receive reflected illumination from said distal end of said guidewire/optical fiber catheter, and to direct said reflected illumination along a third beam path extending from said beam splitting means,

a moveable mirror in said second beam path,

motive means operable to move said movable mirror to a sequence of positions to thereby vary the length of said second beam path, and

illumination interferometer means operable to receive said reflected illumination from said third beam path and to receive illumination from said second beam path, said interferometer means being operable to provide an output comprising an amplitude signal plot as a function of said sequence of positions of said movable mirror.

2. The apparatus of claim 1 wherein said optical fiber means is a single mode optical fiber.

3. The apparatus of claim 1 wherein said optical fiber means further comprises light focusing means at a distal end thereof for expanding said illumination from said source of illumination.

4. The apparatus of claim 1 wherein said guidewire/optical fiber catheter further comprises means for changing the direction in which light from said optical fiber means is directed.

5. The apparatus of claim 3, wherein said light focusing means is further operable for focusing said reflected illumination on a distal end of said optical fiber proximate said distal end of said guidewire/optical fiber catheter.

6. The apparatus of claim 1 wherein said low coherent source of illumination further comprises means for providing said illumination at a plurality of wavelengths.

7. The apparatus of claim 6, wherein said means for providing said illumination at a plurality of wavelengths comprises a tuneable dye laser.

8. The apparatus of claim 6, wherein said means for providing said illumination at a plurality of wavelengths comprises a plurality of superluminescent diodes.

9. The apparatus of claim 6, wherein said means for providing said illumination at a plurality of wavelengths comprises a white light source, monochromator and a plurality of filters.

10. The apparatus of claim 6 wherein said low wherein said interferometer means further comprises photodetector means for detecting each of said plurality of wavelengths.

11. The apparatus of claim 1, further comprising a coupler intermediate said beam splitting means and said proximal end of said guidewire/optical fiber catheter, said coupler providing means for connecting said guidewire/optical fiber catheter to a source of illumination.

12. The apparatus of claim 1, wherein said interferometer means is further operable to provide an output indicative of a cross-section of said tissue.

13. A guidewire/optical fiber catheter having a distal end, said guidewire/optical fiber catheter comprising:

a metal guidewire tube having an inner diameter, an outer diameter, and a first and second end,

a metal extension tube having a first and a second end, an inner diameter, and an outer diameter generally equal in size to the inner diameter of said guidewire tube,

means fastening said first end of said extension tube within the inner diameter of said guidewire tube at said second end of said guidewire tube, said extension tube thereby forming an extension of said guidewire tube with said second end of said extension tube being positioned adjacent to the distal end of said guidewire/optical fiber catheter,

an optical fiber extending generally concentrically within said guide wire tube and said extension tube, said optical fiber having a second end that extends a short distance beyond said second end of said extension tube,

a metal wire coil having a first and a second end, said coil having an outer diameter that is generally equal in size to the outer diameter of said guidewire tube, and an inner diameter that is generally equal in size to the outer diameter of said extension tube,

means fastening said first end of said coil to the outer diameter of said extension tube such that said second end of said coil is generally coextensive with said second end of said optical fiber, and

lens means proximate said second end of said optical fiber, said lens means for positioning said second end of said optical fiber so that said optical fiber is generally concentric with said second end of said coil.

14. The guidewire/optical fiber catheter of claim 13 wherein said metal guidewire tube, said metal extension tube, and said metal wire coil are formed of stainless steel.

15. The guidewire/optical fiber catheter of claim 13 wherein said optical fiber is a single mode optical fiber.

16. The guidewire/optical fiber catheter of claim 13 further comprising a safety wire interconnecting said extension tube and said coil.

17. The guidewire/optical fiber catheter of claim 13 wherein said lens means comprises an epoxy operating to form a lens.

18. The guidewire/optical fiber catheter of claim 13 wherein said distal end of said guidewire/optical fiber catheter is radiopaque.

19. The guidewire/optical fiber catheter of claim 13, wherein said lens means is further operable for expanding illumination exiting said second end of said optical fiber.

20. The guidewire/optical fiber catheter of claim 13, wherein said lens means is further operable for focusing illumination striking said distal end of said guidewire/optical fiber catheter on said second end of said optical fiber.

21. The guidewire/optical fiber catheter of claim 13, wherein said lens means is coated with an optically clear elastomer.

22. The guidewire/optical fiber catheter of claim 13, further comprising means for increasing the lubricity and lowering the surface friction of said guidewire/optical fiber catheter, said means comprising a hydrophilic coating over said guidewire/optical fiber catheter.

23. The guidewire/optical fiber catheter of claim 13, wherein said outer diameter of said guidewire tube and said outer diameter of said wire coil have a maximum of about 0.014 inches.

24. The guidewire/optical fiber catheter of claim 13, further comprising a coupler proximate said first ends of said guidewire tube and said optical fiber, said coupler providing means for connecting said guidewire/optical fiber catheter to a source of illumination.

25. Diagnostic apparatus comprising:

a guidewire/optical fiber catheter having a distal end, said guidewire/optical fiber catheter having a metal guidewire tube having an inner diameter, an outer diameter, and a first and second end, a metal extension tube having a first and a second end, an inner diameter, and an outer diameter generally equal in size to the inner diameter of said guidewire tube, means fastening said first end of said extension tube within the inner diameter of said guidewire tube at said second end of said guidewire tube, said extension tube thereby forming an extension of said guidewire tube with said second end of said extension tube being positioned adjacent to the distal end of said guidewire/optical fiber catheter, an optical fiber extending generally concentrically within said guide wire tube and said extension tube, said optical fiber having a first end proximate said first end of said guidewire tube and a second end that extends a short distance beyond said second end of said extension tube, a metal wire coil having a first and a second end, said coil having an outer diameter that is generally equal in size to the outer diameter of said guidewire tube, and an inner diameter that is generally equal in size to the outer diameter of said extension tube, means fastening said first end of said coil to the outer diameter of said extension tube such that said second end of said coil is generally coextensive with said second of said optical fiber, and lens means proximate said second end of said optical fiber, said lens means for positioning said second end of said optical fiber so that said optical fiber is generally concentric with said second end of said coil,

a low coherent source of illumination adjacent the first end of said optical fiber,

beam splitting means intermediate said source of illumination and the first end of said optical fiber,

said beam splitting means operating to provide a first beam path that extends into the first end of said optical fiber, and operating to provide a second beam path extending off of said beam splitting means,

said beam splitting means also operating to receive illumination from said second end of said optical fiber and to direct said illumination along a third beam path extending off of said beam splitting means,

a movable mirror in said second beam path,

motive means operable to move said movable mirror to a sequence of positions to thereby vary the length of said second beam path, and

illumination interferometer means operable to receive said illumination from said third beam path and to receive illumination from said second beam path, said interferometer means being operable to provide an output facilitating diagnosis of said tissue as a function of said sequence of positions of said movable mirror.

26. The apparatus of claim 25 wherein said optical fiber is a single mode optical fiber.

27. The apparatus of claim 25 wherein said low coherent source of illumination further comprises means for providing said illumination at a plurality of wavelengths.

28. The apparatus of claim 25 wherein said lens means comprises an epoxy for forming a lens.

29. The apparatus of claim 25 wherein said interferometer means further comprises photodetector means for detecting each of said plurality of wavelengths.

30. The apparatus of claim 27, wherein said means for providing said illumination at a plurality of wavelengths comprises a tuneable dye laser.

31. The apparatus of claim 27, wherein said means for providing said illumination at a plurality of wavelengths comprises a plurality of superluminescent diodes.

32. The apparatus of claim 27, wherein said means for providing said illumination at a plurality of wavelengths comprises a white light source, monochromator and a plurality of filters.

33. The apparatus of claim 25, further comprising a coupler proximate said first ends of said guidewire tube and said optical fiber, said coupler providing means for connecting said guidewire/optical fiber catheter to said source of illumination.

34. The apparatus of claim 25, wherein said lens means is further operable for expanding illumination exiting said second end of said optical fiber.

35. The apparatus of claim 25, wherein said lens means is further operable for focusing illumination striking said distal end of said guidewire/optical fiber catheter on said second end of said optical fiber.

36. The apparatus of claim 25, wherein said lens means is coated with an optically clear elastomer.

37. The apparatus of claim 25, further comprising means for increasing the lubricity and lowering the surface friction of said guidewire/optical fiber catheter, said means comprising a hydrophilic coating over said guidewire/optical fiber catheter.

38. The apparatus of claim 25, wherein said outer diameter of said guidewire tube and said outer diameter of said wire coil have a maximum of about 0.014 inches.

39. The apparatus of claim 25, wherein said interferometer means is further operable to provide an output indicative of a cross-section of said tissue.

40. Tissue diagnostic apparatus comprising:

a guidewire/optical fiber catheter having a proximal end and a distal end, and having elongated guidewire means for serving as a guide wire and elongated light conducting optical fiber means for illuminating tissue that is adjacent to the distal end of said guidewire/optical fiber catheter, to thereby produce reflected illumination from the tissue;

a low coherent source of illumination adjacent the proximal end of said guidewire/optical fiber catheter, said source of illumination further comprising means for providing said illumination at a plurality of wavelengths;

beam splitting means intermediate said source of illumination and the proximal end of said guidewire/optical fiber catheter;

said beam splitting means operating to provide a first beam path that extends into the proximal end of said guidewire/optical fiber catheter, and operating to provide a second beam path extending from said beam splitting means;

said beam splitting means also operating to receive reflected illumination from said distal end of said guidewire/optical fiber catheter, and to direct said reflected illumination along a third beam path extending from said beam splitting means;

a coupler intermediate said beam splitting means and said proximal end of said gadder/optical fiber catheter;

a movable mirror in said second beam path;

motive means operable to move said movable mirror to a sequence of positions to thereby vary the length of said second beam path; and

illumination interferometer means operable to receive said reflected illumination from said third beam path and to receive illumination from said second beam path, said interferometer means being operable to provide an output comprising an amplitude signal plot as a function of said sequence of positions of said movable mirror.

41. A guidewire/optical fiber catheter having a distal end, said guidewire/optical fiber catheter comprising:

a metal guidewire tube having an inner diameter, an outer diameter, and a first and second end, said outer diameter having a maximum of about 0.014 inches;

a metal extension tube having a first and a second end, an inner diameter, and an outer diameter generally equal in size to the inner diameter of said guidewire tube;

means fastening said first end of said extension tube within the inner diameter of said gadder tube at said second end of said gadder tube, said extension tube thereby forming an extension of said guidewire tube with said second end of said extension tube being positioned adjacent to the distal end of said guidewire/optical fiber catheter;

an optical fiber extending generally concentrically within said guide wire tube and said extension tube, said optical fiber having a first end proximate said first end of said guidewire tube and a second end that extends a short distance beyond said second end of said extension tube;

a metal wire coil having a first and a second end, said coil having an outer diameter that is generally equal in size to the outer diameter of said guidewire tube, and an inner diameter that is generally equal in size to the outer diameter of said extension tube;

means fastening said first end of said coil to the outer diameter of said extension tube such that said second end of said coil is generally coextensive with said second end of said optical fiber;

a coupler proximate said first ends of said guidewire tube and said optical fiber, said coupler providing means for connecting said guidewire/optical fiber catheter to a source of illumination;

lens means proximate said, second end of said optical fiber is said lens means for positioning said second end of said optical fiber so that said optical fiber generally concentric with said second end of said coil, for expanding illumination exiting said second end of said optical fiber, and for focusing illumination striking said distal end of said guidewire/optical fiber catheter on said second end of said optical fiber;

an optically clear elastomer coating said lens means; and

means for increasing the lubricity and lowering the surface friction of said guidewire/optical fiber catheter, said means comprising a hydrophilic coating over said guidewire/optical fiber catheter.

42. Diagnostic apparatus comprising:

a guidewire/optical fiber catheter having a distal end, said guidewire/optical fiber catheter having a metal guidewire tube having an inner diameter, an outer diameter with a maximum of about 0.014 inches, and a first and second end, a metal extension tube having a first and a second end, an inner diameter, and an outer diameter generally equal in size to the inner diameter of said guidewire tube, means fastening said first end of said extension tube within the inner diameter of said guidewire tube at said second end of said gadder tube, said extension tube thereby forming an extension of said guidewire tube with said second end of said extension tube being positioned adjacent to the distal end of said guidewire/optical fiber catheter, an optical fiber extending generally concentrically within said guide wire tube and said extension tube, said optical fiber having a first end proximate said first end of said guidewire tube and a second end that extends a short distance beyond said second end of said extension tube, a metal wire coil having a first and a second end, said coil having an outer diameter that is generally equal in size to the outer diameter of said guidewire tube, and an inner diameter that is generally equal in size to the outer diameter of said extension tube, means fastening said first end of said coil to the outer diameter of said extension tube such that said second end of said coil is generally coextensive with said second of said optical fiber, and lens means proximate said second end of said optical fiber, said lens means for positioning said second end of said optical fiber so that said optical fiber is generally concentric with said second end of said coil, said lens means also for expanding illumination exiting said second end of said optical fiber and said lens mens further for focusing illumination striking said distal end of said guidewire/optical fiber catheter on said second end of said optical fiber;

a low coherent source of illumination adjacent the first end of said optical fiber, said source of illumination further comprising means for providing said illumination at a plurality of wavelengths;

beam splitting means intermediate said source of illumination and the first end of said optical fiber;

said beam splitting means operating to provide a first beam path that extends into the first end of said optical fiber, and operating to provide a second beam path extending off of said beam splitting means;

said beam splitting means also operating to receive illumination from said second end of said optical fiber and to direct said illumination along a third beam path extending off of said beam splitting means;

a coupler intermediate said beam splitting means and said first ends of said guidewire tube and said optical fiber, said coupler providing means for connecting said guidewire/optical fiber catheter to said source of illumination;

a movable mirror in said second beam path;

motive means operable to move said movable mirror to a sequence of positions to thereby vary the length of said second beam path; and

illumination interferometer means operable to receive said illumination from said third beam path and to receive illumination from said second beam path, said interferometer means further comprising photodetector means for detecting each of said plurality of wavelengths, said interferometer means further being operable to provide an output facilitating diagnosis of said tissue as a function of said sequence of positions of said movable mirror.