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Iontophoretic administration of drugs

  • US 5,383,848 A
  • Filed: 04/04/1991
  • Issued: 01/24/1995
  • Est. Priority Date: 04/12/1990
  • Status: Expired due to Fees
First Claim
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1. An improved method of iontophoretic administration of a drug to a subject comprising the steps of:

  • selecting a site on the subject'"'"'s skin for iontophoretic administration of the drug;

    administering a formulation capable of increasing blood flow to the subject'"'"'s skin near the site and prior to iontophoretic administration of the drug;

    allowing sufficient time to pass for the formulation to effect increased flow of blood in the skin near the site on the subject'"'"'s skin; and

    iontophoretically administering the drug to the subject at the site;

    wherein said formulation includes from about 0.1 to about 5% methyl nicotinate and from about 0.02% to about 0.3% capsaicin in a vehicle of which comprises a short chain aliphatic alcohol, light mineral oil or propylene glycol and methyl salicylate, in a ratio which comprises about 2 to about 6 parts alcohol and about 1 to about 4 parts mineral oil or propylene glycol per part methyl salicylate.

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