Pre-filled injection device comprising a barrel wherein a liquid diazepam formulation is accommodated

• US 5,383,864 A
• Filed: 12/14/1992
• Issued: 01/24/1995
• Est. Priority Date: 03/28/1989
• Status: Expired due to Fees

• Current Assignee: Duphar International Research B.V. (Abbott Laboratories Incorporated)
• Original Assignee: Duphar International Research B.V. (Abbott Laboratories Incorporated)
• Inventors: van den Heuvel, Johan G.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US07/990,929
• Time in Patent Office: 771 Days
• Field of Search: 604/192, 604/194-196, 604/201-202, 604/218, 604/232
• US Class Current: 604/218
• CPC Class Codes: A61J 1/062 Carpules
• CPC Class Codes: A61M 2005/1787 Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 2005/3139 Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001

Abstract

The invention relates to a pre-filled injection device, comprising (i) a barrel which is open at each end in which, before using the device, a liquid diazepam formulation is accommodated in a sealed manner and which comprises at least one rubber sealing member to seal the said formulation, and (ii) an injection needle or a needle connection at the front end of the barrel, said sealing member being manufactured at least substantially from bromobutyl rubber.

Claims

1. A pre-filled injection device, comprising (i) a barrel which is open at each end in which, before using the device, a liquid diazepam formulation is sealingly accommodated and which comprises at least one rubber sealing member to seal said formulation, and (ii) a needle connection means for connecting an injection needle at the front end of the barrel, wherein said sealing member is manufactured from bromobutyl rubber.

2. An injection device as claimed in claim 1, in which the liquid diazepam formulation, before using the device, is sealingly accommodated between two rubber members in the barrel, wherein the sealing members are manufactured from bromobutyl rubber.

3. A pre-filled injection device for the automatic injection of injection liquid under the influence of a power source, comprising, in addition to the power source, a barrel, which is open at each end, to the front end of which an injection needle is attached and in which a liquid diazepam formulation is accommodated between two rubber sealing members, wherein the sealing members are manufactured from bromobutyl rubber.

4. An automatic injection device as claimed in claim 3, in which the diazepam formulation is accommodated between two stoppers which are movable in the barrel wherein both stoppers are manufactured from bromobutyl rubber.

5. An automatic injection device as claimed in claim 3, in which the diazepam formulation is accommodated between a piston and a stopper, each of which is movable in the barrel, wherein the piston and the stopper are manufactured from bromobutyl rubber.