Prosthetic implant with self-generated current for early fixation in skeletal bone

• US 5,383,935 A
• Filed: 09/28/1993
• Issued: 01/24/1995
• Est. Priority Date: 07/22/1992
• Status: Expired due to Fees

• Current Assignee: Morteza Shirkhanzadeh
• Original Assignee: Morteza Shirkhanzadeh
• Inventors: Shirkhanzadeh, Morteza
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US08/127,491
• Time in Patent Office: 483 Days
• Field of Search: 623/11, 623/16, 623/18, 623/66, 433/173, 433/174
• US Class Current: 623/23.49
• CPC Class Codes: A61C 8/00 Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools fastening of peg-teeth in the mouth A61C13/30
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30771 applied in original prostheses, e.g. holes or grooves
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2821 Bone stimulation by electromagnetic fields or electric current for enhancing ossification
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30772 Apertures or holes, e.g. of circular cross section
• CPC Class Codes: A61F 2002/30968 Sintering
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2310/00023 Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/378 Electrical supply

Abstract

A prosthetic implant for implantation into skeletal bone comprising an implantable base member having an internal housing surrounded partially by a porous wall, an anode secured in the internal housing in electrical contact with the porous wall, and a porous means placed in the internal housing for retaining a biocompatible electrolyte. When implanted into bone structure, the prosthetic implant generates sufficient current flow which results in invivo formation of calcium phosphate minerals between the implant and the surrounding bone, thereby, resulting in improved fixation and stability of the implant.

Claims

1. A prosthetic implant for use as a body implant and for stimulating bone formation in close proximity of said implant comprising:

An implantable base member consisting of an internal housing and a conductive porous wall, said porous wall surrounding said internal housing at least partially, said porous wall having an outer surface on which bone attachment is desired, an inner surface and a plurality of apertures extending from said inner surface through said wall to said outer surface, and adapted for tissue ingrowth when said prosthetic implant is implanted in the body;

a porous means located in said internal housing retaining a biocompatible electrolyte, said electrolyte being in contact with said inner surface of said porous wall;

an anode also secured within said internal housing, said anode being in contact with said electrolyte and means for electrically connecting said anode to said porous wall so as to form a galvanic couple and to generate sufficient current flow to induce precipitation of calcium phosphate minerals on said outer surface of said porous wall and to stimulate bone growth into said porous wall.

2. A prosthetic implant according to claim 1 wherein said implantable base member is formed of titanium or titanium-based alloys.

3. A prosthetic implant according to claim 1 wherein said outer surface of said porous wall has at least one roughened area to enhance fixation of the implant in skeletal bone.

4. A prosthetic implant according to claim 1 wherein said apertures have diameters less than 5 mm.

5. A prosthetic implant according to claim 1 wherein said anode is porous.

6. A prosthetic implant according to claim 1 wherein said anode contains calcium, magnesium and combination thereof.

7. A prosthetic implant according to claim 1 wherein said anode is made of a metal hydride charged with hydrogen.

8. A prosthetic implant according to claim 1 wherein said porous means is made of ceramic.

9. A prosthetic implant according to claim 1 wherein said porous means is made of a biocompatible calcium phosphate ceramic of the apatite group.

10. A prosthetic implant according to claim 1 wherein said porous means is made of tricalcium phosphate (TCP).

11. A prosthetic implant according to claim 1 wherein said porous means is made of a conductive material selected from the group consisting of metal hydrides charged with hydrogen and alloys containing calcium, magnesium or combination thereof.

12. A prosthetic implant according to claim 1 wherein said porous means contains biologically active substances selected from the group consisting of bone morphogenic protein (BMP), collagen and antibiotics.

13. A prosthetic implant according to claim 1 wherein said bio-compatible electrolyte contains Ca- and P- bearing ions and a pH ranging from about 3 to 8.

14. A prosthetic implant according to claim 1 wherein said implantable base member is in the form of a dental root implant.

15. A prosthetic implant according to claim 1 wherein said implantable base member is in the form of a femoral component of a hip prosthesis.

16. A prosthetic implant for permanent fixation in skeletal bone having means for rapidly inducing precipitation of calcium phosphate minerals at the interface between said implant and bone, and thereby, enhancing the stability of said implant comprising:

An implantable base member consisting of an internal housing and a conductive porous wall, said porous wall surrounding said internal housing at least partially, said porous wall having an outer surface on which bone attachment is desired, an inner surface and a plurality of apertures extending from said inner surface through said wall to said outer surface, and adapted for tissue ingrowth when said prosthetic implant is implanted in the body;

a porous means located in said internal housing for absorbing and retaining body fluid when said prosthetic implant is implanted in the body;

an anode also secured within internal housing and means for electrically connecting said anode to said porous wall so as to form a galvanic couple when said prosthetic implant is implanted in the body and to generate sufficient current flow to induce precipitation of calcium phosphate minerals on said outer surface of said porous wall and to stimulate bone growth into said porous wall.