Diurea derivatives useful as medicaments and processes for the preparation thereof

• US 5,384,425 A
• Filed: 10/07/1993
• Issued: 01/24/1995
• Est. Priority Date: 01/20/1988
• Status: Expired due to Fees

• Current Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Astellas Pharma Incorporated)
• Original Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Astellas Pharma Incorporated)
• Inventors: Yasunaga, Tomoyuki, Iizumi, Yuichi, Araki, Tomio, Ito, Noriki
• Primary Examiner(s): Kumar, Shailendra
• Application Number:
  US08/064,850
• Time in Patent Office: 474 Days
• Field of Search: 560/138, 560/142, 560/130, 514/529, 514/546, 514/547, 514/548, 514/585, 564/26, 564/27, 564/29
• US Class Current: 560/138
• CPC Class Codes: C07C 2601/14 The ring being saturated
• CPC Class Codes: C07C 2601/18 with a ring being at least seven-membered
• CPC Class Codes: C07C 275/26 having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
• CPC Class Codes: C07C 275/28 having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• CPC Class Codes: C07C 275/30 being further substituted by halogen atoms, or by nitro or nitroso groups
• CPC Class Codes: C07C 275/34 having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
• CPC Class Codes: C07C 275/40 being further substituted by nitrogen atoms not being part of nitro or nitroso groups
• CPC Class Codes: C07C 335/14 having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
• CPC Class Codes: C07D 213/75 Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Abstract

Diurea derivatives are provided which can be represented by the following general formula and salts thereof: ##STR1## wherein, R¹ and R² are the same or different, and each represents C¹ -10 alkyl group, a C³ -18 cycloalkyl group, or a lower alkyl group substituted by cycloalkyl radical(s);

R³, R⁴, R⁵ and R⁶ are the same or different, and each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, hydrocarbyl aralkyl group, a pyridyl group, or an unsubstituted or substituted phenyl group, the substituents of the phenyl group being selected from a group consisting of lower alkyl radical, halogen atom-substituted lower alkyl radical, halogen atom, nitro radical, amino radical, mono- or di-lower alkylamino radical, lower acylamino radical, hydroxyl radical, lower alkoxy radical and lower acyloxy radical;

X represents an oxygen atom or a sulfur atom, and n¹ and n² represent an integer of 1 to 6; and wherein at least one of R³ -R⁶ is a phenyl substituted by acyloxy.

Claims

1. 1,3-Bis[[3-(p-acetoxyphenyl)-1-cycloheptylureido]methyl]benzene.