Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium

• US 5,385,147 A
• Filed: 09/22/1993
• Issued: 01/31/1995
• Est. Priority Date: 09/22/1993
• Status: Expired due to Fees

• Current Assignee: Molecular Biosystems, Inc (Alliance Pharmaceutical Corporation)
• Original Assignee: Molecular Biosystems, Inc (Alliance Pharmaceutical Corporation)
• Inventors: Bartlett, Janeth M., Anderson, Leslie D., Widder, Kenneth J., Szaflarski, Diane M.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US08/125,621
• Time in Patent Office: 496 Days
• Field of Search: 128/660.01, 128/660.06, 128/662.02, 128/661.02, 424/439, 424/9
• US Class Current: 600/458
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61K 49/226 Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Abstract

A method for enhanced ultrasonic imaging of the tissues defining the gastrointestinal tract and the upper abdominal organs wherein the gastrointestinal tract is filled with a chemically defined essentially sonolucent ultrasound contrast agent that is stable under gastric conditions and has a gastric emptying time of at least about twenty minutes, thus causing the lumen of the upper gastrointestinal tract to appear dark relative to the positive image of the gastrointestinal tract walls and upper abdominal organs.

Claims

1. (Amended) A method of ultrasonic imaging of tissue defining the gastrointestinal tract and organs in the upper abdominal region comprising:

a) introducing a sufficient amount of a chemically defined essentially sonolucent and nonechogenic ultrasound contrast agent solution that is stable under gastric conditions and has a gastric emptying time of at least about twenty minutes into the stomach to substantially fill the stomach and remove gas by displacement, dispersion and absorption from the imaging field;

b) applying ultrasonic energy to the stomach and upper abdominal region while said solution is present in the gastrointestinal tract, said energy passing through the solution and being reflected by said tissue and said organs; and

c) forming an image from the reflected energy.

2. The method of claim 1 wherein the gastric emptying time is about twenty minutes to two hours.

3. The method of claim 1 wherein the solution has an osmolality ≧

300 millimoles per kilogram.

4. The method of claim 1 wherein the solution is degassed prior to introduction.

5. The method of claim 1 wherein said solution contains a solute selected from the group consisting of polydextrose, maltodextrin, corn syrup, glycerin and mixtures thereof.

6. The method of claim 5 wherein the concentration of the solute is 10% to 50% weight per volume.

7. The method of claim 1 wherein said solution contains polydextrose.

8. The method of claim 1 wherein said solution contains maltodextrin.

9. The method of claim 1 wherein said solution contains corn syrup.

10. The method of claim 1 wherein said solution contains glycerin.

11. The method of claim 1 wherein said solution contains an acid selected from the group consisting of amino acids and fatty acids.

12. The method of claim 1 wherein said solution contains an amino acid.

13. The method of claim 1 wherein said solution contains a fatty acid.

14. The method of claim 1 wherein said solution contains a glyceride.

15. The method of claim 1 wherein said solution contains a monoglyceride.

16. The method of claim 1 wherein said solution contains a diglyceride.

17. The method of claim 1 wherein said solution contains a triglyceride.

18. The method of claim 1 wherein said solution contains L-tryptophan.

19. The method of claim 1 wherein said solution contains an agent that binds calcium ions at gastric pH.