Adhesive composition and method

• US 5,385,606 A
• Filed: 03/22/1993
• Issued: 01/31/1995
• Est. Priority Date: 07/06/1992
• Status: Expired due to Term

• Current Assignee: Cryolife Incorporated
• Original Assignee: Nicholas Kowanko
• Inventors: Kowanko, Nicholas
• Primary Examiner(s): Kight, III, John
• Assistant Examiner(s): MULLIS, JEFFREY C
• Application Number:
  US08/034,184
• Time in Patent Office: 680 Days
• Field of Search: 106/125, 106/124, 527/205, 530/829, 530/830, 530/380, 524/17, 524/18, 524/9, 524/10, 524/354, 524/541, 602/50, 602/904, 604/307, 606/154, 606/153, 424/443, 424/444, 424/43, 514/2
• US Class Current: 106/156.3
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/106 Fibrin; Fibrinogen
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C09J 189/00 Adhesives based on proteins; Adhesives based on derivatives thereof

Abstract

An adhesive composition, primarily intended as a tissue adhesive, comprised of cross-linked proteinaceous material, and methods for its use.

Claims

1. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is human serum albumin.

2. The composition of claim 1 wherein the aldehyde is glutaraldehyde.

3. The composition of claim 1 wherein the concentration of protein is about 40-47 weight %.

4. The composition of claim 1 wherein the concentration of protein is about 35 to 43% by weight.

5. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is animal serum albumin and the aldehyde is glutaraldehyde.

6. The composition of claim 5 wherein the concentration of protein is about 40-47 weight %.

7. The composition of claim 5 wherein the concentration of protein is about 35 to 43% by weight.

8. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di-or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is bovine serum albumin.

9. The composition of claim 8 wherein the aldehyde is glutaraldehyde.

10. The composition of claim 8 wherein the concentration of protein is about 40-47 weight %.

11. The composition of claim 8 wherein the concentration of protein is about 35 to 43% by weight.

12. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di-or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is concentrated human blood serum.

13. The composition of claim 12 wherein the aldehyde is glutaraldehyde.

14. The composition of claim 12 wherein the concentration of protein is about 40-47 weight %.

15. The composition of claim 12 wherein the concentration of protein is about 35 to 43% by weight.

16. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is ovalbumin.

17. The composition of claim 16 wherein the aldehyde is glutaraldehyde.

18. The composition of claim 16 wherein the concentration of protein is about 40-47 weight %.

19. The composition of claim 16 wherein the concentration of protein is about 35 to 43% by weight.