Horseradish preparation for the treatment of nasal and sinus dysfunction

• US 5,385,734 A
• Filed: 05/27/1993
• Issued: 01/31/1995
• Est. Priority Date: 03/02/1992
• Status: Expired due to Fees

• Current Assignee: Horseradish Spray, Inc.
• Original Assignee: Horseradish Spray, Inc.
• Inventors: Friedman, William H.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): AZPURU, CARLOS A
• Application Number:
  US08/068,998
• Time in Patent Office: 614 Days
• Field of Search: 424/195.1, 424/434, 424/489, 514/951, 426/615
• US Class Current: 424/434
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 36/31 Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

A method of treatment for nasal and sinus dysfunction is disclosed comprising topically applying a horseradish, sinigrin or allyl isothiocyanate preparation to affected mucosa. Preparations for the treatment of nasal and sinus dysfunction are also disclosed, including preparations of horseradish, sinigrin and allyl isothiocyanate.

Claims

1. A formulation for the treatment of nasal or sinus dysfunction comprising an aqueous salt dispersion of solid horseradish particles having a mean particle diameter not greater than 20 microns, said dispersion containing from 0.01 to 10.0 weight percent of the horseradish particles.

2. The formulation of claim 1, wherein the mean particle diameter of the horseradish particles is from 2-10 microns.

3. The formulation of claim 1, wherein the pH of the dispersion is from 5-7.

4. The formulation of claim 1, wherein the dispersion contains from 0.6-0.7 weight percent sodium chloride.

5. The formulation of claim 1, wherein the dispersion of horseradish particles contains from 3.0 to 10.0 weight percent of horseradish particles having a mean particle diameter of from 2-10 microns.

6. The formulation of claim 1, wherein the dispersion of horseradish particles contains from 8.0-10.0 weight percent of horseradish particles having a mean particle diameter of from 2-10 microns.

7. The formulation of claim 1, containing from 0.5-0.8% by weight of a dissolved salt selected from the group consisting of sodium chloride, a potassium salt, a magnesium salt and mixtures thereof.

8. The formulation of claim 1, wherein the dispersion contains sodium chloride.

9. The formulation of claim 8, wherein the dispersion contains from 0.5 to 0.8 weight percent sodium chloride.

10. The formulation of claim 1, comprising an aqueous saline dispersion of horseradish particles having a mean particle diameter not greater than 20 microns, said dispersion containing from 0.01 to 10.0 weight percent of the horseradish particles and from 0.5 to 0.8 weight percent sodium chloride.