Implantable non-enzymatic electrochemical glucose sensor

• US 5,387,327 A
• Filed: 10/19/1992
• Issued: 02/07/1995
• Est. Priority Date: 10/19/1992
• Status: Expired due to Fees

• Current Assignee: Duquesne University of The Holy Ghost
• Original Assignee: Duquesne University of The Holy Ghost
• Inventors: Khan, Shahed U. M.
• Primary Examiner(s): Tung, T.
• Application Number:
  US07/962,667
• Time in Patent Office: 841 Days
• Field of Search: 204/402, 204/403, 204/415
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A non-enzymatic implantable glucose blood detector. The detector makes use of a non-reactive tin oxide semiconductor measurement electrode which is suitably energized by an electrical power source. Variations in current density at the measurement electrode are related to variations in glucose content of blood. The device also uses variable voltage to allow the electrode to be self-cleaning.

Claims

1. An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor measurement electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening permitting glucose molecules to pass therethrough to said measurement electrode, but resisting the passage therethrough of molecules of predetermined greater size, said measurement electrode being connected to monitoring means for monitoring current density at said measurement electrode, in response to glucose molecules oxidation or glucose molecules reduction reactions at said measurement electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.

2. The detector of claim 1, wherein said power source creates a continuous variable voltage, thereby maintaining said electrode in a clean state.

3. The detector of claim 1, wherein said non-reactive semiconductor measurement electrode is fabricated from a semiconductor material selected from the group consisting of tin oxide and titanium dioxide.

4. The detector of claim 3, wherein said sleeve member comprises a venturi tube having an opening for allowing said glucose molecules to pass therethrough but precludes passage therethrough of molecules larger than about 100,000 M.W.

5. An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening covered with a biocompatible membrane having a pore size permitting glucose molecules to pass therethrough to said electrode, but resisting the passage therethrough of molecules sized greater than about 100,000 M.W., said electrode being connected to monitoring means for monitoring current density at said electrode, in response to glucose oxidation or glucose reduction reactions at said electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.

6. The detector of claim 5, wherein said power source creates a continuous variable voltage, thereby maintaining said electrode in a clean slate.

7. The detector of claim 5, wherein said non-reactive semiconductor electrode is fabricated from a semiconductor material selected from the group consisting of tin oxide and titanium dioxide.