System for controlled release of antiarrhythmic agents
First Claim
1. A method of making a device for controlled release of an antiarrhythmic drug comprising:
- (a) forming a mixture of about 4 parts lidocaine hydrochloride;
10 parts polyurethane prepolymer, said polyurethane prepolymer comprising about 0.21 parts diisocyanate monomer and about 0.79 parts polyether monomer; and
about 0.74 μ
M FeCl3 /g polyether monomer;
(b) forming the mixture into a desired shape; and
(c) curing the formed mixture at a temperature in the range of 50°
C. to 60°
C. for a period of time ranging from about 24 hours to 3 days.
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Abstract
A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.
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Citations
1 Claim
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1. A method of making a device for controlled release of an antiarrhythmic drug comprising:
-
(a) forming a mixture of about 4 parts lidocaine hydrochloride;
10 parts polyurethane prepolymer, said polyurethane prepolymer comprising about 0.21 parts diisocyanate monomer and about 0.79 parts polyether monomer; and
about 0.74 μ
M FeCl3 /g polyether monomer;(b) forming the mixture into a desired shape; and (c) curing the formed mixture at a temperature in the range of 50°
C. to 60°
C. for a period of time ranging from about 24 hours to 3 days.
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Specification
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- Resources
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Current AssigneeUniversity of Michigan
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Original AssigneeUniversity of Michigan
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InventorsSintov, Amnon, Levy, Robert J.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)Hulina, Amy
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Application NumberUS08/037,810Time in Patent Office683 DaysField of Search424/423, 424/424, 424/425, 424/422, 514/821, 604/891.1, 607/129, 607/120US Class Current424/422CPC Class CodesA61K 9/0024 Solid, semi-solid or solidi...A61K 9/7007 Drug-containing films, memb...
