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Coated capillary tube for the controlled release of reagent

  • US 5,387,526 A
  • Filed: 03/30/1993
  • Issued: 02/07/1995
  • Est. Priority Date: 09/11/1990
  • Status: Expired due to Fees
First Claim
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1. A container, which is constructed so as to be mounted in a spectrometer and which is used for detecting the presence of or quantifying the amount of a biopolymer or biopolymers in a sample solution that is introduced into the container, comprising:

  • a micropipette or capillary tube that is transparent to at least a portion of the electromagnetic spectrum emitted and detected by a spectrometer and that is constructed so as to be mounted in the spectrometer whereby light passes through the walls of said tube; and

    a coating composition deposited on the inner wall of said tube, wherein;

    the coating contains one or more reagents and a binding agent;

    wherein the binding agent delays distribution of the reagent in the sample solution for at least about 5 seconds to permit uniform dissolution upon filling, and which said binding agent contains one or more ingredients selected from the group consisting of a sugar, a polysaccharide, a gelatin, a polyacrylamide, and agarose,the reagent specifically interacts with one or more biopolymers in the sample solution to form complexes, whereby, upon exposure to electromagnetic radiation emitted by the spectrometer through the walls of the tube, the complexes absorb or emit electromagnetic radiation; and

    the coating contains a sufficient amount of the reagent(s) in the coating to permit detection of the complexes by the spectrometer.

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