Methods and apparatus for sensing intracardiac signals for an inplantable cardiac pacemaker

• US 5,388,586 A
• Filed: 12/23/1993
• Issued: 02/14/1995
• Est. Priority Date: 12/23/1992
• Status: Expired due to Term

• Current Assignee: Ela Medical S.A. (LivaNova Plc)
• Original Assignee: Ela Medical S.A. (LivaNova Plc)
• Inventors: Claudon, Laurent, Lee, Chik-Yam, Molin, Renzo D.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US08/172,847
• Time in Patent Office: 418 Days
• Field of Search: 128/696, 128/697, 128/702, 128/704, 128/903, 607/9, 607/18, 607/27, 341/143, 375/27, 375/28
• US Class Current: 600/517
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

A circuit for use in an implantable cardiac pacemaker for use in processing intracardiac signals and methods of processing such signals. The circuit includes a passive filter 1 has a bandwidth of 0.1 to 80 Hz approximately. An amplifier 2 with switched capacitors presents at the output a dynamics of 0.8V approximately and a gain lower than 50. An analog-to-digital converter 3 with delta modulation, which is controllably variable in step and functions at two frequencies, one of 1 kHz approximately, the other of 4 kHz approximately. The circuit may be used for both processing said signals to identify spontaneous cardiac events and to telemeter an intracardiac ECG.

Claims

1. An apparatus for acquiring and detecting intracardial cardiac activity signals comprising:

a passive filter having a passband width of from 0.1 Hz to 80 Hz, an input for receiving cardiac activity signals, and an output for providing filtered signals;

an amplifier integrated circuit including switched capacitors and having an input for receiving the filtered signals, a gain lower than 50, and an output for providing amplified signals in a dynamic range of approximately 0.8V;

an analog-to-digital converter with delta modulation, having a controllable frequency and step for converting an input analog signal to a digital value, an input for receiving the amplified signals, and an output for providing digital values corresponding to the amplified signals;

processor means for processing the digital values; and

means for detecting spontaneous cardiac events based on the processed digital values.

2. The apparatus of claim 1 characterized in that the analog-to-digital converter controllable frequency further comprises at least two frequencies that are separately selectable.

3. The apparatus of claim 2 wherein the two frequencies are approximately 1 kHz, and approximately 4 kHz, and the processor means further comprises an output command signal for controlling the analog-to-digital converter to operate at one of the two frequencies.

4. The apparatus of claim 1 wherein the amplifier circuit gain and dynamic range are selected to detect atrial and/or ventricular spontaneous events, and further comprising means for measuring the parameter of efficiency of stimulation, and means for transmitting an intracardial ECG by telemetry based on said digital values.

5. The apparatus of claim 4, further comprising means for automatically adjusting the period of blanking.

6. The apparatus of claim 4, further comprising means for automatically adjusting the sensitivity.

7. The apparatus of claim 6 wherein the automatic sensitivity adjustment means further comprises means for determining the absolute value of the maximal amplitude variation of the signal sensed during a plurality of successive first durations beginning with a detected spontaneous cardiac event and ending a second period following said detected event;

and

means for determining the maximal amplitude variation for a plurality of consecutive cardiac events; and

means for calculating the sensitivity as a first percentage of the average of the plurality of maximal values.

8. The apparatus of claim 7, wherein the automatic sensitivity adjustment means further comprises means for providing an initial sensitivity value based on a programmed value multiplied by a constant value, wherein the maximal amplitude determining means determines the maximal value following a stimulated cardiac event as the initial sensitivity value.

9. The apparatus of claim 8 wherein the constant value is the inverse of the first percentage, the first percentage is on the order of 37.5%, and the first plurality of consecutive cardiac events is eight cardiac cycles.

10. The apparatus of claim 4 wherein the processor means further comprises:

means for determining an absolute value of the variation of amplitude of a plurality of the digital values sensed during a first duration, the first duration being selected in the range of from 6 to 12 ms;

means for comparing said determined absolute value to an acceleration threshold; and

means for selecting the frequency and step of analog-to-digital converter based on said comparison.

11. The apparatus of claim 1 wherein the processor means further comprises means for determining an absolute value of the variation of amplitude of a plurality of digital values of the signal sensed during the first duration, the first duration being selected in the range from 6 to 12 ms, means for comparing said absolute value to a detection threshold, and means for determining a detection of an atrial or ventricular spontaneous cardiac event based on said comparison.

12. The apparatus of claim 11 further comprising:

means for controlling the absolute value determining means to determine a first sign of a variation of amplitude and first amplitude variation and a second sign of a variation of amplitude and second amplitude variation, the first sign and first amplitude being based on a first plurality of digital values sensed during said first duration at a time before the end of an absolute refractory period, and the second sign and second amplitude being based on a second plurality of digital values sensed during said first duration at a time after the end of an absolute refractory period;

second means for comparing the first and second signs and amplitudes; and

means for indicating a spontaneous cardiac event in response to the absolute value of the second amplitude being greater than the detection threshold and the second sign being of opposite polarity to the first sign.

13. The apparatus of claim 11 wherein the processor means further comprises a microcontroller dedicated to perform numerical processing of the digital values to detect intracardial cardiac activity.

14. The apparatus of claim 11 further comprising:

means for determining an amplitude of cross-talk in response to an identified atrial stimulation;

means for providing a ventricular blanking interval in response to an atrial stimulation; and

means for automatically adjusting the ventricular blanking interval based on said determined cross-talk amplitude following an atrial stimulation.

15. The apparatus of claim 14 further comprising means for controlling the absolute value determining means to determine the sign of the variation of amplitude for the first plurality of digital values sensed during each of a plurality of successive first durations, said plurality of first durations beginning after the atrial stimulation, wherein the adjusting means adjusts the end of the ventricular blanking interval to correspond to the occurrence in time of the one first duration having a sign that is the inverse of the sign of the preceding first durations of said plurality of first durations.

16. The apparatus of claim 14 further comprising;

means for determining a value VLB as the base line digital value at the moment of stimulation in response to an atrial stimulation;

means for determining a value VFB as the digital value at the end of the ventricular blanking interval;

wherein the absolute value determining means further comprises;

means for determining the difference between the values VFB and VLB as the deflection and the sign of deflection;

means for comparing the determined deflection to the deflection threshold;

means for determining whether the determined deflection is greater than the detection threshold and in response thereto determining the absolute value and sign of the variation of amplitude for a plurality of digital values sensed during a first duration at the end of the ventricular blanking interval, wherein the identifying means identifies a ventricular event based on the comparison of said absolute amplitude value and said detection threshold.

17. The apparatus of claim 16 wherein the identifying means further comprises means for identifying a ventricular event based on the comparison of said absolute amplitude value and said detection threshold and said sign of said variation of amplitude being the same as the sign of the determined deflection.

18. A method of processing electrical signals corresponding to intracardiac activity comprising:

(a) filtering the electrical signals to suppress frequencies below 0.1 Hz and above 80 Hz;

(b) providing an amplifier integrated circuit having switched capacitors, a dynamic range of 0.8V and a gain of less than 50, and amplifying the filtered signal by said amplifier;

(c) providing a digital to analog converter (ADC) having delta modulation and a controllable frequency and step;

(d) selecting the ADC frequency and step based on previously sensed amplified signals;

(e) converting said amplified signals to digital values by said ADC at the selected frequency and step; and

(f) processing said digital values to identify the occurrence of spontaneous atrial and/or ventricular cardiac events.

19. The method of claim 18 wherein step (d) further comprises selecting the frequency to be one of 1.0 kHz and 4.0 kHz.

20. The method of claim 18 further comprising processing selected ones of said digital values to measure the parameter of efficiency.

21. The method of claim 18 further comprising telemetering a portion of said digital values to a remote location for display of an intracardial ECG.

22. The method of claim 18 further comprising processing selected ones of said digital values and automatically adjusting a period of blanking following a cardiac stimulation.

23. The method of claim 18 further comprising processing selected ones of said digital values and automatically adjusting the sensitivity.

24. The method of claim 23 wherein automatically adjusting the sensitivity further comprises determining the absolute value of the maximal amplitude variation of a plurality of digital values sensed during a first duration for a plurality of successive first durations beginning with a detected spontaneous cardiac event and ending a second period following said detected event;

determining the maximal amplitude variation for a plurality of consecutive cardiac events; and

calculating the sensitivity as a first percentage of the average of the plurality of maximal values.

25. The method of claim 24, wherein automatically adjusting the sensitivity further comprises providing an initial sensitivity value based on a programmed value multiplied by a constant value, and determining the maximal amplitude value following a stimulated cardiac event as the initial sensitivity value.

26. The method of claim 25 further comprising selecting the constant value to be the inverse of the first percentage, selecting the first percentage to be on the order of 37.5%, and selecting the plurality of consecutive cardiac events to be eight cardiac cycles.

27. The method of claim 18 wherein step (f) further comprises:

determining an absolute value of the variation of amplitude of a plurality of digital values sensed during a first duration, the first duration being selected from between 6 and 12 ms;

comparing the determined absolute value to an acceleration threshold; and

performing step (d) to control the frequency and step of the analog to digital converter in response to said comparison.

28. The method of claim 18 wherein step (f) further comprises:

(i) determining an absolute value of the variation of amplitude of a plurality of digital values sensed during a first duration, the first duration being selected from between 6 and 12 ms;

(ii) comparing the determined absolute value to a detection threshold; and

(iii) determining the occurrence of a spontaneous atrial and/or ventricular cardiac event based on said comparison.

29. The method of claim 28 wherein step (f) further comprises:

determining a first sign of a variation of amplitude and first absolute amplitude variation and a second sign of a variation of amplitude and second absolute amplitude variation, the first sign and first absolute amplitude being based on a first plurality of digital values sensed during said first duration at a time before the end of an absolute refractory period, and the second sign and second absolute amplitude being based on a second plurality of digital values sensed during said first duration at a time after the end of an absolute refractory period;

comparing the first and second signs and amplitudes; and

indicating a spontaneous cardiac event in response to the absolute value of the second amplitude being greater than the detection threshold and the second sign being of opposite polarity to the first sign.

30. The method of claim 28 further comprising providing a microcontroller that is dedicated to numeric processing of the digital values to identify spontaneous cardiac events.

31. The method of claim 28 further comprising:

determining an amplitude of cross-talk in response to an identified atrial stimulation;

providing a ventricular blanking interval in response to an atrial stimulation; and

automatically adjusting the ventricular blanking interval based on said determined cross-talk amplitude following an atrial stimulation.

32. The method of claim 31 further comprising determining the sign of the variation of amplitude for the first plurality of digital values sensed during each of a plurality of successive first durations, said plurality of first durations beginning after the atrial stimulation, wherein the adjusting step adjusts the end of the ventricular blanking interval to correspond to the one first duration having a sign that is the inverse of the sign of the preceding first durations of said plurality of first durations.

33. The method of claim 31 further comprising;

determining a base line digital value VLB in response to an atrial stimulation as the digital value at the moment of stimulation;

determining a digital value VFB as the digital value at the end of the ventricular blanking interval;

determining the difference between the values VFB and VLB as the deflection and the sign of deflection;

comparing the determined deflection to the deflection threshold; and

determining whether the determined deflection is greater than the detection threshold and in response thereto determining the absolute value and sign of the variation of amplitude for a plurality of digital values sensed during a first duration at the end of the ventricular blanking interval, and identifying a ventricular event based on the comparison of said absolute amplitude value and said detection threshold.

34. The method of claim 33 wherein the identifying step further comprises identifying a ventricular event based on the comparison of said absolute amplitude value and said detection threshold and said sign of said variation of amplitude being the same as the sign of the determined deflection.

35. A circuit for processing electrical signals corresponding to intracardiac activity for an implantable cardiac pacemaker comprising:

a band pass filter having low cutoff frequency at about 0.1 Hz and a high cutoff frequency at about 80 Hz;

an amplifier integrated circuit having switched capacitors, a low gain of less than 50, and a dynamic range on the order of 0.8V, said amplifier being connected to the filter to amplify the filtered electrical signals;

a digital to analog converter (ADC) having delta modulation and a controllable frequency and step for converting an analog signal to a digital value, said ADC being controlled to convert said amplified signals to digital values.

36. The circuit of claim 35 wherein the analog to digital converter is controllable to have at least a first frequency and a second frequency, and a first step and a second step.

37. The circuit of claim 36 wherein the first frequency is 1.0 kHz and the second frequency is 4.0 kHz.

38. The circuit of claim 35 wherein the amplifier is a differential amplifier.

39. An implantable cardiac monitoring device comprising:

a lead for receiving electrical signals corresponding to intracardiac electrical activity;

a band pass filter having low cutoff frequency at about 0.1 Hz and a high cutoff frequency at about 80 Hz, the filter having an input connected to said lead and an output;

an amplifier integrated circuit having switched capacitors, a low gain of less than 50, and a dynamic range on the order of 0.8V, said amplifier being connected to the filter output to amplify the filtered electrical signals;

a analog to digital converter (ADC) having delta modulation and a controllable frequency and step for converting an analog signal to a digital signal, said ADC being controlled to convert said amplified signals to digital values.

40. The device of claim 39 further comprising:

processing means for processing the digital values to identify spontaneous cardiac activity; and

means for telemetering the digital values out of the pacemaker to provide a intra cardiac ECG for display.

41. The apparatus of claim 40 wherein the cardiac monitoring device is a pacemaker.