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Method and apparatus for in vivo electroporation of remote cells and tissue

  • US 5,389,069 A
  • Filed: 09/17/1993
  • Issued: 02/14/1995
  • Est. Priority Date: 01/21/1988
  • Status: Expired due to Fees
First Claim
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1. A method for treating at least one cell, in vivo, comprising the steps of:

  • a) directing a penetrator into an organism, said penetrator including a first electrode, and an opening through which a chemical agent can be injected into the organism proximate to the cell to be treated;

    b) placing a second electrode where the cell and the opening of the penetrator are between the first and second electrodes;

    c) injecting the chemical agent into the organism through the penetrator in an amount sufficient to treat the cell during electroporation of the cell; and

    d) applying a voltage between the first and second electrodes in an amount sufficient to cause electroporation of at least a portion of the cell, whereby the chemical agent migrates across the cell membrane, thereby treating the cell.

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