Method for locating tumors prior to needle biopsy

• US 5,396,897 A
• Filed: 05/03/1993
• Issued: 03/14/1995
• Est. Priority Date: 01/16/1992
• Status: Expired due to Term

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Boucher, Yves, Stacy-Clear, Adam, Kopans, Daniel B., Jain, Rakesh K., Moore, Richard
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Tucker, Guy V.
• Application Number:
  US08/058,682
• Time in Patent Office: 680 Days
• Field of Search: 128/748, 128/749, 128/751, 128/754, 128/736, 128/630, 128/635, 128/774, 128/898
• US Class Current: 600/561
• CPC Class Codes: A61B 2090/3904 specially adapted for marking specified tissue
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence

Abstract

A method for locating a lesion within a tissue mass, includes steps of measuring a selected parameter at two or more points in at least one path through the tissue mass, the measure of the selected parameter in a lesion being different from that in normal tissue. Also, apparatus for measuring a tissue parameter at two or more points in at least one path through the tissue mass includes an insertion needle, distally sharpened and made sufficiently rigid so that it can be inserted distal end foremost into the tissue mass along the path, and, insertible with the needle, a sensor capable of prodding a measure of the tissue parameter at a point in the tissue mass along the path. Where the parameter is selected as one that has a measure different in a lesion type, the apparatus can be used in carrying out the method, whereby a measure at a point in the tissue mass of the selected tissue parameter provided by the sensor indicates that the point is within a lesion. In an embodiment for measuring interstitial fluid pressure in the tissue mass, the sensor includes a tube slidably engageable within the lumen of the insertion needle; the sensor tube is closed at a distal end, and the walls of the sensor tube and the insertion needle are prodded distally with ports, positioned in relation to the respective distal ends such that when the sensor tube is engaged within the insertion tube lumen the ports can be substantially aligned to provide fluid communication between the lumen of the sensor tube and the tissue adjacent the ports; the sensor tube lumen contains a plurality of filaments, and is operationally connected to a pressure measurement deuce such that the pressure measurement deuce is responsive to fluid pressure within the sensor tube lumen.

Claims

1. A method for determining the locus of a pathologic condition within a tissue mass, comprising the steps of:

(a) inserting into the tissue mass a sensor including a sensor tube closed at a distal end, the sensor tube disposed within a lumen of an insertion tube, the insertion tube having an open distal end, the insertion tube provided with a first aperture adjacent the open end thereof, the sensor tube-provided with a second aperture adjacent the closed end thereof, said sensor capable of measuring at least interstitial fluid pressure;

(b) aligning the first and second apertures of the insertion and sensor tubes, respectively, so that at least part of the sensor tube is in interstitial fluid communication with the tissue mass;

(c) measuring interstitial fluid pressure at a point in a path through the tissue mass while at least part of the sensor tube is in interstitial fluid communication with the tissue mass;

(d) measuring interstitial fluid pressure at another point in said path through the tissue mass while at least part of the sensor tube is in interstitial fluid communication with the tissue mass;

(e) repeating steps (c) through (d), wherein a first increase in interstitial fluid pressure is an indication of a pathologic condition in the tissue mass;

(f) removing said sensor tube from said insertion tube and inserting a tissue marker into the insertion tube so that it extends from the open distal end of the insertion tube into the tissue mass at a point within said tissue mass where said pathologic condition is located.

2. The method of claim 1, further comprising the step of removing said insertion tube from said tissue mass and leaving said tissue marker in said tissue mass at the point where said pathologic condition is located.

3. The method of claim 1, wherein the step of inserting a tissue marker comprises inserting a hookwire.

4. The method of claim 1, wherein said pathologic condition is a tumor.

5. A method for marking the location of a tumor within a tissue mass, comprising the steps of:

inserting into the tissue mass a sensor including a sensor tube closed at a distal end, said sensor tube disposed within a lumen of an insertion tube having an open distal end, said insertion tube provided with a first aperture adjacent the open end thereof, said sensor tube provided with a second aperture adjacent the closed end thereof, said sensor capable of measuring at least interstitial fluid pressure;

(b) aligning the first and second apertures of the insertion and sensor tubes, respectively, so that at least part of the sensor tube is in communication with the tissue mass;

(c) measuring at least interstitial fluid pressure at a point in the tissue mass while at least part of the sensor tube is in communication with the tissue mass, wherein a first increase in at least interstitial fluid pressure is an indication that the insertion and sensor tubes have entered a tumor in the tissue mass;

(d) removing said sensor tube from said insertion tube and inserting a tissue marker into the insertion tube so that it extends from the open distal end of the insertion tube into the tissue mass at a point within said tissue mass where the tumor is located; and

(e) removing said insertion tube from said tissue mass and leaving said tissue marker in said tissue mass at the point where the tumor is located.