Methods of and apparatus for measuring uterine electrical and mechanical activity

• US 5,397,344 A
• Filed: 12/22/1992
• Issued: 03/14/1995
• Est. Priority Date: 12/22/1992
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Schering Ag (Merck & Co., Inc.)
• Inventors: Garfield, Robert, Chwalisz, Krzysztof, Bukowski, Radoslaw
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US07/995,180
• Time in Patent Office: 812 Days
• Field of Search: 128/420.5, 128/639, 128/642, 128/733, 128/734, 128/783, 128/784, 128/786, 128/788, 607/39, 607/115, 607/116, 607/138
• US Class Current: 607/138
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/391 of genito-urinary organs
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The existence of gap junctions between cells is detected by stimulating the cells with electrical pulses having selective parameters and then detecting propagated signals emitted by the cells. A needle is provided having stimulation electrodes thereon from which the stimulating pulses emanate and an array of recording electrodes for detecting the pulses. In an alternative embodiment, an array of piezoelectric electrodes is distributed within the array of recording electrodes. The signals detected by the recording electrodes and piezoelectric electrodes are monitored by a recording device and stored within a computer.

Claims

1. In a combination with a recording device for monitoring and recording electrical signals, a needle useful for insertion into tissue having cells with gap junctions occurring therebetween, which cells generate electrical signals that propagate by gap junctions upon stimulation of the cells, the needle comprising:

a hollow shank having an axis and a central cavity within which tissue is received;

an array of recording electrodes disposed within the hollow shank for contact with the tissue therein, each of the recording electrodes having a first lead extending therefrom back to the recording device;

an array of stimulation electrodes disposed in the hollow shank in spaced relation with respect to the recording electrodes for contact with the tissue therein, each stimulation electrode having a lead extending therefrom back to the recording device;

the recording device including means connected to the second leads for applying stimulation signals over the second leads to the stimulation electrodes wherein the cells generate signals for detection by the recording electrodes and wherein the recording device includes means connected to the first leads extending from the recording electrodes for processing the signals.

2. The combination of claim 1, further including an array of piezoelectric electrodes disposed in the shank of the needle for detecting muscle contractions.

3. The combination of claim 1, wherein the stimulation electrodes and recording electrodes are axially spaced from one another with respect to the axis of the shank.

4. The combination of claim 3, further including an array of piezoelectric electrodes disposed in alternating fashion within the array of recording electrodes.

5. The combination of claim 4, wherein the stimulation electrodes are positioned proximate the tip of the needle with the recording and piezoelectric electrodes disposed between the stimulation electrodes proximate the end of the shank.

6. The combination of claim 5, wherein since the needle is hollow, whereby the needle may be used to withdraw fluid from a patient while alternatively monitoring the state of the cells with the electrodes.

7. An arrangement for detecting electrical coupling of cells in tissue by monitoring gap junctions between the cells, the arrangement comprising:

a needle for insertion into the tissue, the needle having a hollow shank portion with a point for penetrating the tissue and isolating a portion of the cells from the remaining cells;

at least one recording electrode within the hollow shank portion with a first lead extending from the recording electrode;

at least one stimulation electrode within the hollow shank portion with a second lead extending from the stimulating electrode;

a recording device including means connected to the second lead for applying stimulation signals to the stimulation electrode wherein the cells generate gap junction signals for detection by the recording electrode and the recording device further including means connected to the first lead for processing the gap junction signals.

8. The arrangement of claim 7, wherein the tissue is smooth muscle tissue and wherein the hollow shank portion of the needle is configured to penetrate smooth muscle tissue.

9. The arrangement of claim 7, wherein the tissue is uterine wall muscle tissue and wherein the hollow shank portion of the needle is configured to .penetrate the uterine wall muscle tissue.

10. The arrangement of claim 7, wherein there are a plurality of recording electrodes within the hollow shank portion spaced from one another.

11. The arrangement of claim 10, wherein there are a plurality of piezoelectric electrodes disposed within the hollow shank portion in alternating fashion among the recording electrodes.

12. A needle useful for monitoring gap junction discharges in a mass of tissue, the needle comprising:

a shank with a point for penetrating the tissue and a bore extending from the point, wherein the bore receives a portion of the tissue therein to isolate the portion from the remaining mass of tissue;

at least one recording electrode in the bore with a first lead extending therefore;

at least one stimulating electrode in the bore with a second lead extending therefrom whereby upon applying a current pulse to the first lead to stimulate a gap junction discharge in the portion of tissue, the discharge is detected by the recording electrode for monitoring by a recording device connected to the first lead.

13. The needle of claim 12, wherein there are a plurality of recording electrodes each with a first lead.

14. The needle of claim 13, wherein there are a plurality of stimulation electrodes each with a second lead.

15. The needle of claim 13, further including an array of piezoelectric electrodes disposed among the recording electrodes.