Implant tissue

• US 5,397,353 A
• Filed: 01/03/1991
• Issued: 03/14/1995
• Est. Priority Date: 05/24/1984
• Status: Expired due to Term

• Current Assignee: Covidien AG (Medtronic Plc)
• Original Assignee: Roy A. Grant, Roy F. Oliver
• Inventors: Oliver, Roy F., Grant, Roy A.
• Primary Examiner(s): ISABELLA, DAVID J
• Application Number:
  US07/637,172
• Time in Patent Office: 1,531 Days
• Field of Search: 623/1, 623/2, 623/11, 623/12, 623/15, 623/16, 623/66, 424/422, 424/423, 128/DIG. 8
• US Class Current: 600/36
• CPC Class Codes: A61L 27/3695 characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this A61L27/3687, A61L27/3691 take precedence
• CPC Class Codes: C08H 1/06 derived from horn, hoofs, hair, skin or leather

Abstract

A collagenous tissue preparation suitable for homotransplantation or heterotransplantion. The preparation is a non-resorbable, non-antigenic collagenous material which retains the natural structure and original architecture of the natural tissue. The material is substantially free of non-fibrous tissue proteins, glycoproteins, cellular elements and lipids. The tissue preparation is recolonized by host cells and revascularized after implantation into the host.

Claims

1. A non-resorbable, substantially non-antigenic collagenous fibrous tissue preparation of human or animal tissue origin, which is suitable for homo- or heterotransplantation as a permanent repair for cutaneous wounds and soft tissue injuries, which preparation retains the natural structure and original architecture of said human or animal tissue, is substantially free of non-fibrous tissue proteins and glycoproteins, is substantially free of cellular elements, is substantially free of lipids and lipid residues and is non-cytotoxic, wherein said preparation is capable when implanted of being recolonized by host cells and revascularized while being resistant to calcification.

2. A preparation as claimed in claim 1 additionally substantially free of antigenic polysaccharides and mucopolysaccharides.

3. A preparation as claimed in any one of the preceding claims when in the form of a sheet.

4. An implant for the permanent repair of cutaneous or soft tissue injuries in humans which comprises a sheet of substantially non-antigenic collageneous fibrous tissue preparation of claim 1.

5. An implant as claimed in claim 4 in which the implant is derived from pig dermis.

6. An implant as claimed in either of claims 4 or 5 in which the implant is formed from a sheet of fibrous collagenous tissue which has been cross-linked by means of a polyisocyanate.

7. An implant as claimed in claim 6 in which the polyisocyanate is hexamethylene diisocyanate.