Co-extraction of azadirachtin and neem oil

• US 5,397,571 A
• Filed: 03/25/1993
• Issued: 03/14/1995
• Est. Priority Date: 03/25/1993
• Status: Expired due to Term

• Current Assignee: Certis USA LLC (Mitsui & Company Limited)
• Original Assignee: W R Grace & Company - CONN (Standard Industries Holdings, Inc.)
• Inventors: Roland, Michael T., Blouin, John J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/036,795
• Time in Patent Office: 719 Days
• Field of Search: 424/405, 424/195.1, 514/453
• US Class Current: 424/405
• CPC Class Codes: C07H 19/01 sharing oxygen
• CPC Class Codes: C11B 1/10 by extracting
• CPC Class Codes: C11B 1/108 after-treatment, e.g. of miscellae

Abstract

Disclosed is an improved method of extracting neem seeds. The method involves co-solvent extracting neem seeds with a solvent mixture of a nonpolar, aliphatic hydrocarbon solvent and a polar solvent to simultaneously remove the hydrophilic and hydrophobic extracts from the neem seeds. The method provides novel neem extract mixtures which contain both the hydrophobic and hydrophilic portion Of the neem seeds. The extract mixtures may be further extracted to yield an azadirachtin-containing solid product having greater than 10 weight percent of azadirachtin.

Claims

1. A solid neem product having greater than 10 weight percent of azadirachtin and being prepared by

(a) extracting neem seeds with a co-solvent mixture of a polar solvent and a nonpolar, aliphatic hydrocarbon solvent to obtain a co-solvent neem extract;

(b) removing the solvent from the co-solvent neem extract to recover a neem extract mixture;

(c) contacting the neem extract mixture with a solvent having a sufficiently low polarity to precipitate a solid having an azadirachtin content of greater than 10 weight percent.

2. The neem product of claim 1 having an azadirachtin content of at least 15 weight percent.

3. The neem product of claim 1 wherein the aliphatic hydrocarbon solvent in step (c) is pentane, hexane, heptane, octane, nonane, decane, isoctane, chloropentane, chlorohexane, isomers thereof, or mixtures thereof.

4. The neem product of claim 1 wherein the polar solvent is selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, 2-butanol, t-butanol, benzyl alcohol and mixtures thereof.

5. The neem product of claim 1 wherein the aliphatic hydrocarbon solvent and polar solvent of step (a) are miscible and form a homogenous co-solvent mixture.

6. The neem product of claim 1 wherein the co-solvent mixture comprises from about 10 to about 90 weight percent of the aliphatic hydrocarbon solvent and from about 90 to about 10 weight percent of the polar solvent.