Enhancing the hydrophilicity of silicone polymers
First Claim
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1. A method for incorporating a hydrophilic component into a silicone polymer material which comprises:
- introducing a hydrophilic component into a silicone polymeric material selected from the group consisting of cross-linked silicone polymeric materials and solid silicone polymer materials, said hydrophilic component including a hydrophilic portion and a silicone polymer portion; and
subjecting said hydrophilic component and said silicone polymeric material to conditions effective to physically immobilize at least a portion of said hydrophilic component and form a silicone polymer material which is optically clear and includes said hydrophilic component physically immobilized in and distributed throughout said silicone polymer material in an amount effective to provide increased hydrophilicity to said silicone polymer material relative to a substantially identical polymer material without said hydrophilic component, provided said subjecting is ineffective to increase or decrease the degree of polymerization or the degree of cross-linking of said silicone polymeric material, and said silicone polymer material is utilized without further substantial polymerization or cross-linking.
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Abstract
Methods for incorporating hydrophilic constituents into silicone polymer materials are disclosed. In one embodiment, the method comprises introducing a hydrophilic component into a cross-linked and/or solid silicone polymeric material, and subjecting the hydrophilic component to conditions effective to immobilize the hydrophilic component or a hydrophilic derivative thereof and form a silicone polymer material including an effective hydrophilic constituent.
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Citations
16 Claims
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1. A method for incorporating a hydrophilic component into a silicone polymer material which comprises:
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introducing a hydrophilic component into a silicone polymeric material selected from the group consisting of cross-linked silicone polymeric materials and solid silicone polymer materials, said hydrophilic component including a hydrophilic portion and a silicone polymer portion; and subjecting said hydrophilic component and said silicone polymeric material to conditions effective to physically immobilize at least a portion of said hydrophilic component and form a silicone polymer material which is optically clear and includes said hydrophilic component physically immobilized in and distributed throughout said silicone polymer material in an amount effective to provide increased hydrophilicity to said silicone polymer material relative to a substantially identical polymer material without said hydrophilic component, provided said subjecting is ineffective to increase or decrease the degree of polymerization or the degree of cross-linking of said silicone polymeric material, and said silicone polymer material is utilized without further substantial polymerization or cross-linking. - View Dependent Claims (2, 3, 4)
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5. A method for incorporating a hydrophilic constituent into a silicone polymer material which comprises:
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introducing a hydrophilic component including a hydrophilic portion and a silicone polymer portion into a silicone polymeric material selected from the group consisting of cross-linked silicone polymeric materials and solid silicone polymeric materials so as to distribute said hydrophilic component throughout said silicone polymeric material; and subjecting said hydrophilic component and said silicone polymeric material to conditions effective to chemically react said hydrophilic component with said silicone polymeric material, thereby forming a silicone polymer material which is optically clear and includes a covalently bonded hydrophilic constituent derived from said hydrophilic component distributed throughout said silicone polymer material in an amount effective to provide enhanced hydrophilicity to said silicone polymer material relative to said silicone polymeric material, provided said subjecting is ineffective to increase or decrease the degree of polymerization or the degree of cross-linking of said silicone polymeric material, and said silicone polymer material is utilized without further substantial polymerization or cross-linking. - View Dependent Claims (6, 7)
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8. A method for incorporating a hydrophilic constituent into a silicone polymer material which comprises:
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forming a precursor mixture containing two or more silicon-containing components in amounts effective to polymerize and form a silicone polymeric material, and a hydrophilic component including a hydrophilic portion and a silicone polymer portion; and subjecting said precursor mixture to conditions effective to polymerize said two or more silicon-containing components, immobilize said hydrophilic component or a hydrophilic derivative thereof, and form a silicone polymer material which is optically clear and sufficiently elastomeric to form an optic of a foldable intraocular lens and includes a hydrophilic constituent in an amount effective to provide enhanced hydrophilicity to said silicone polymer material relative to a substantially identical silicone polymer material without said hydrophilic constituent. - View Dependent Claims (9, 10)
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- 11. A foldable intraocular lens comprising a foldable optic including an optically clear silicone polymer material being sufficiently elastomeric to form said optic of said foldable intraocular lens and including immobilized a hydrophilic constituent selected from the group consisting of a hydrophilic component and a hydrophilic derivative thereof in an amount effective to provide increased hydrophilicity to said silicone polymer material relative to a substantially identical polymer material without said hydrophilic constituent, said hydrophilic component including a hydrophilic portion and a silicone polymer portion, said hydrophilic constituent being distributed throughout and immobilized in said silicone polymer material without an increase or decrease in the degree of polymerization or the degree of cross-linking of said silicone polymer material, and said silicone polymer material is utilized without further substantial polymerization or cross-linking.
- 14. A composition comprising an optically clear silicone polymer material which is sufficiently elastomeric to produce an optic of a foldable intraocular lens and includes an immobilized hydrophilic constituent selected from the group consisting of a hydrophilic component and a hydrophilic derivative thereof in an amount effective to provide increased hydrophilicity to said silicone polymer material relative to a substantially identical polymer material without said hydrophilic constituent, said hydrophilic component including a hydrophilic portion and a silicone polymer portion, said hydrophilic constituent being uniformly distributed throughout and immobilized in said silicone polymer material without an increase or decrease in the degree of polymerization or the degree of cross-linking of said silicone polymer material, and said silicone polymer material is utilized without further substantial polymerization or cross-linking.
Specification