Collagen-containing sponges as drug delivery compositions for proteins

• US 5,399,361 A
• Filed: 06/28/1994
• Issued: 03/21/1995
• Est. Priority Date: 05/01/1992
• Status: Expired due to Term

• Current Assignee: Amgen Inc.
• Original Assignee: Amgen Inc.
• Inventors: Morawiecki, Andrew, Song, Suk-Zu
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Azpuru, Carlos
• Application Number:
  US08/268,063
• Time in Patent Office: 266 Days
• Field of Search: 424/78.06, 424/423, 424/443, 424/445, 424/485, 424/486, 424/488, 514/801, 514/944, 514/953, 128/DIG. 8, 606/229
• US Class Current: 424/486
• CPC Class Codes: A61K 9/2063 Proteins, e.g. gelatin
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 15/325 Collagen
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 128/08 Collagen

Abstract

Collagen-containing sponges comprising an absorbable gelatin sponge, collagen, and an active ingredient are disclosed as are methods of enhancing wound healing of external and internal wounds using such sponges.

Claims

1. A collagen-containing sponge comprising an absorbable, cross-linked gelatin sponge, soluble collagen, and a therapeutically effective amount of an active ingredient.

2. A collagen-containing sponge according to claim 1 wherein said absorbable gelatin sponge is a crosslinked gelatin.

3. A collagen-containing sponge according to claim 2 further comprising a plasticizer.

4. A collagen-containing sponge according to claim 3 wherein said plasticizer is selected from polyethylene glycol and glycerol.

5. A collagen-containing sponge according to claim 3 further comprising a stabilizing agent.

6. A collagen-containing sponge according to claim 5 wherein said stabilizing agent is a sugar selected from the group consisting of mannitol, lactose and glucose.

7. A collagen-containing sponge according to claim 5 further comprising a drying enhancer.

8. A collagen-containing sponge according to claim 7 wherein said drying enhancer is an alcohol selected from the group consisting of ethanol, methanol and isopropyl alcohol.

9. A collagen-containing sponge according to claim 7 further comprising a buffer.

10. A collagen-containing sponge according to claim 1 wherein said active ingredient is selected from the group consisting of PDGF, EGF, FGF, PDEGF, PD-ECGF, KGF, IGF-1, IGF-2, TNF, BDNF, CNTF, and NT-3.

11. A collagen-containing sponge according to claim 9 wherein said active ingredient is selected from the group consisting of PDGF, EGF, FGF, PDEGF, PD-ECGF, KGF, IGF-1, IGF-2, TNF, BDNF, CNTF, and NT-3.

12. A collagen-containing sponge according to claim 10 wherein said active ingredient is KGF.

13. A collagen-containing sponge according to claim 11 wherein said active ingredient is KGF.