Blood processing for treating blood disease

• US 5,401,237 A
• Filed: 06/26/1992
• Issued: 03/28/1995
• Est. Priority Date: 06/28/1991
• Status: Expired due to Term

• Current Assignee: Shunro Tachibana
• Original Assignee: Shunro Tachibana
• Inventors: Sogawa, Ichiro, Tachibana, Katsuro, Tachibana, Shunro
• Primary Examiner(s): Rimell, Sam
• Application Number:
  US07/905,245
• Time in Patent Office: 1,005 Days
• Field of Search: 604/4, 604/5, 604/6, 604/19, 128/660.03, 204/157.62
• US Class Current: 604/4.01
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: H04R 17/08 signals being recorded or played back by vibration of a stylus in two orthogonal directions simultaneously

Abstract

A method and an apparatus for an effective chemical treatment of a blood disease apply a drug of a wider range with a smaller dose or lower concentration to the blood outside the patient'"'"'s body. Blood which is collected from a patient is fed through a tube (2a) into a chamber (4) by a pump (3). A drug is injected into the chamber (4) from a container (5), while ultrasonic waves are applied to the blood contained in the chamber (4) from an actuator (7). The blood treated with the drug and by the ultrasonic waves, is returned into the body of the patient through a tube (2c), while the same is monitored by sensors (10) and (11).

Claims

1. An apparatus for processing blood, comprising a passage having an inlet and an outlet for passing blood therethrough;

a pump for feeding said blood from said inlet toward said outlet in said passage;

drug injection means for injecting a drug into said passage; and

ultrasonic wave application means for improving an effectiveness of said drug on a component of said blood by applying ultrasonic waves to said blood mixed with said drug in said passage.

2. The apparatus in accordance with claim 1, further comprising a treatment sensor for monitoring relevant blood characteristics of said blood discharged from said passage.

3. The apparatus in accordance with claim 1, further comprising removal means for removing said drug from said blood flowing in said passage after injection of said drug.

4. The apparatus in accordance with claim 1, wherein said passage comprises a tube for introducing said blood, and a chamber connected with said tube for mixing said blood with said drug while applying ultrasonic waves therein.

5. The apparatus in accordance with claim 4, wherein said ultrasonic wave application means comprise an ultrasonic transmission element provided in said chamber, an ultrasonic transmission control circuit outside said chamber, and means connecting said ultrasonic transmission element to said ultrasonic transmission control circuit outside said chamber.

6. The apparatus in accordance with claim 1, as applied to an external circulation system for treating a patient.

7. A method for processing blood, comprising:

(a) feeding blood into a treatment passage at a treatment rate;

(b) adding a quantity of a drug to said blood in said passage;

(c) applying ultrasonic waves to said blood containing said drug in said treatment passage, for improving an effectiveness of said drug on a component of said blood; and

(d) discharging ultrasonic-treated blood from said passage.

8. The method in accordance with claim 7, further comprising monitoring treatment relevant characteristics of said blood discharged from said treatment passage.

9. The method in accordance with claim 7, further comprising removing said drug left in said blood before discharge of said blood from said treatment passage.

10. The method of claim 7, wherein said blood is whole blood and said blood is not separated during any step of said method, wherein said ultrasonic waves are applied to said whole blood.

11. The method of claim 7, wherein said blood is not heated above normal body temperatures during said method.

12. The method of claim 7, wherein said blood component is a component other than red cells.

13. The method of claim 12, wherein said blood component is lymphocytic cells.

14. A method of treating a patient having a blood disease, said method comprising:

(a) collecting blood from said patient;

(b) adding a drug to said collected blood;

(c) applying ultrasonic waves to said blood containing said drug for improving an effectiveness of said drug on a component of said blood; and

(d) returning ultrasonic-treated blood into the body of said patient.

15. The method in accordance with claim 14, further comprising correlating a definite volume of said blood continuously collected from said patient to a prescription dose of said drug and to a prescription dose of said ultrasonic waves, and then continuously returning treated blood into the body of said patient.

16. The method in accordance with claim 14, further comprising removing said drug still left in said blood after said application of ultrasonic waves and before said blood is returned into the body of said patient.

17. The method in accordance with claim 14, further comprising monitoring said ultrasonic-treated blood for treatment relevant characteristics.

18. The method in accordance with claim 14, wherein a disease of said blood is leukemia.

19. The method in accordance with claim 14, wherein said drug includes a carcinostatic substance.

20. The method in accordance with claim 18, wherein said drug includes a carcinostatic substance.

21. The method of claim 14, wherein said blood is whole blood and said blood is not separated during any step of said method, wherein said ultrasonic waves are applied to said whole blood.

22. The method of claim 14, wherein said blood is not heated above normal body temperatures during said method.

23. The method of claim 14, wherein said blood component is a component other than red cells.

24. The method of claim 23, wherein said blood component is lymphocytic cells.