Lactic acid acylates

• US 5,401,773 A
• Filed: 02/06/1991
• Issued: 03/28/1995
• Est. Priority Date: 02/22/1990
• Status: Expired due to Fees

• Current Assignee: Boots Company PLC (Walgreens Boots Alliance Incorporated)
• Original Assignee: Roussel-Uclaf
• Inventors: Noel, Hugues
• Primary Examiner(s): Dees, Jose G.
• Assistant Examiner(s): Carr, Deborah D.
• Application Number:
  US07/651,466
• Time in Patent Office: 1,511 Days
• Field of Search: 260/410.6, 554/223, 554/227, 514/547, 514/549, 514/552, 514/886, 514/887
• US Class Current: 514/547
• CPC Class Codes: A61K 31/23 of acids having a carboxyl group bound to a chain of seven or more carbon atoms
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: C07C 67/08 by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
• CPC Class Codes: C07C 69/68 Lactic acid esters

Abstract

All possible isomeric forms, racemic mixtures and enantiomeric and diastereoisomeric forms of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R is alkenyl of 10 carbon atoms, n is an integer from 1 to 3 and their non-toxic salts useful for treating comedones.

Claims

1. All possible isomeric forms, racemic mixtures and enantiomeric and diastereoismeric forms of a compound selected from the group consisting of a compound of the formula ##STR3## wherein R is alkenyl of 10 carbon atoms, n is an integer from 1 to 3 and their non-toxic salts.

2. A compound of claim 1 wherein n is 1 or 2 and R is CH₂ ═

CH--(CH₂)₈ --.

3. A compound of claim 1 which is 10-undecenoyl 1-lactylic acid and its salts.

4. A composition for treating comedones comprising a comedonically effective amount of at least one compound of claim 1 and a cosmetic or pharmaceutical carrier.

5. A composition of claim 4 wherein n is 1 or 2 and R is CH₂ ═

CH--(CH₂)₈ --.

6. A composition of claim 4 wherein the active ingredient is 10-undecenoyl 1-lactylic acid or its salts.

7. A method of treating comedones in warm-blooded animals comprising applying to the skin of warm-blooded animals a comedonically effective amount of at least one compound of claim 1.

8. A method of claim 7 wherein n is 1 or 2 and R is CH₂ ═

CH--(CH₂)₈ --.

9. A method of claim 7 wherein the active ingredient is -undecenoyl 1-lactylic acid or its salts.