Methods for measuring perfusion using magnetic resonance imaging

• US 5,402,785 A
• Filed: 08/16/1991
• Issued: 04/04/1995
• Est. Priority Date: 08/16/1991
• Status: Expired due to Term

• Current Assignee: Carnegie Mellon University, Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Carnegie Mellon University, Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Williams, Donald S., Detre, John A., Koretsky, Alan P., Leigh, John S.
• Primary Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US07/746,771
• Time in Patent Office: 1,327 Days
• Field of Search: 128/653.1, 128/653.2, 128/653.3, 128/653.4, 324/306, 324/307, 324/309
• US Class Current: 600/419
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/56341 Diffusion imaging

Abstract

Methods for measuring the perfusion of fluid in a substance are shown to include subjecting the fluid to electromagnetic energy so as to cause a response related to the magnetization of the fluid before it enters the substance, performing magnetic resonance measurements on the substance to generate intensity information and processing the intensity information to determine perfusion. In one embodiment of the invention, perfusion is measured by labeling atoms in the fluid at a base point, generating a steady state in the substance by continuing to label atoms until the effect caused by labeled atoms perfusing in the substance, reaches a steady state, generating image information for the substance and processing the image information to determine perfusion. It is preferred to label atoms by applying magnetic resonance perturbation. In one embodiment the labeling of atoms involves saturating spins associated with the atoms. In an especially preferred embodiment labeling involves inverting spins associated with the atoms continuously by adiabatic fast passage. Such inversion is preferably achieved by applying a radio frequency field virtually continuously. The invention is particularly useful where the substance is tissue and wherein the fluid is blood. In such an embodiment, labeling involves labeling the hydrogen atoms of water contained in the blood. It is also preferred for labeling to occur at a point between the heart and the tissue. It is also especially preferred for the generation of magnetic resonance images to involve generating a first image while labeling at the base point, labeling at a remote point, generating a second image while labeling at the remote point and generating a relaxation image. In such an embodiment, all of the images are processed in the determination of perfusion.

Claims

1. A method for measuring the perfusion of fluid into a mass without requiring the use of an exogenous tracer and wherein the fluid passes a labelling position prior to perfusion into said mass, said method comprising the steps of:

magnetically labelling atoms in said fluid at said labelling position to produce labelled atoms;

allowing the labelled atoms in said fluid to perfuse into said mass;

generating image information, representing images with and without said labelled atoms, for the mass containing said fluid; and

processing said image information to determine the quantity of said fluid per quantity of said mass per unit time which has perfused into said mass.

2. The method of claim 1, wherein the step of magnetically labelling atoms comprises the step of applying magnetic resonance perturbation to said labelling position.

3. The method of claim 2, wherein the step of magnetically labelling atoms comprises the step of saturating a spin associated with said atoms.

4. The method of claim 3, wherein the step of saturating a spin comprises the steps of applying a slice selective 90°

pulse and applying a gradient homospoil pulse.

5. The method of claim 2, wherein the step of magnetically labelling atoms comprises the step of inverting spins associated with said atoms substantially continuously by adiabatic fast passage.

6. The method of claim 5, wherein the step of substantially continuously inverting spins comprises the step of repeatedly applying a radio frequency field.

7. The method of claim 6, wherein said radio frequency field comprises a center frequency and said step of generating image information comprises the step of controlling the spatial location of the point of spin inversion by offsetting said center frequency.

8. The method of claim 1, wherein said mass is tissue and said fluid is blood, and said step of magnetically labelling further comprises the step of labelling hydrogen atoms of water contained in said blood.

9. The method of claim 8, wherein said tissue is an organ and said step of labelling hydrogen atoms of water contained in said blood comprises the step of magnetically labelling at a labelling position between the heart and the organ so as to label water being carried from the heart to the organ.

10. The method of claim 9, wherein said organ is a brain and said step of magnetically labelling comprises the step of labelling the neck.

11. The method of claim 1, wherein said step of generating image information for said mass comprises the step of generating magnetic resonance images of said mass.

12. The method of claim 11, wherein said step of generating magnetic resonance images comprises the steps of generating a first image of said mass while said step of magnetically labelling at said labelling position is being performed, magnetically labelling at a location remote from said labelling position, generating a second image of said mass while said step of magnetically labelling at said remote location is being performed, and generating a relaxation image of said mass.

13. The method of claim 12, wherein said step of processing said image information comprises the step of processing the image information associated with said first and second images and said relaxation image.

14. The method of claim 13, wherein the step of processing the image information associated with said first and second images and said relaxation image comprises processing such information according to the formula:

##EQU13## where M_b^inv is the image information associated with said first image, M_b^cont is the image information associated with said second image, T_1app is the image information associated with said relaxation image, α

=2 when said magnetically labelling step comprises the step of inverting spins associated with said atoms continuously by adiabatic fast passage and α

=1 when said magnetically labelling step comprises the step of saturating a spin associated with said atoms, and f is the quantity of said fluid per quantity of said mass per unit time which has perfused into said mass.

15. The method of claim 14, wherein said relaxation image comprises pixels and T_1app is calculated from progressive saturation images by fitting each pixel of said relaxation image to a monoexponential curve.

16. The method of claim 14, wherein T_1app is generated by applying a saturation recovery imaging sequence comprising a plurality of recovery times and spins which are continuously inverted.

17. The method of claim 1, further comprising the step of applying symmetrical spoiler gradient pulses during the step of generating image information.

18. The method of claim 1, wherein said step of generating image information comprises the steps of applying a multi-echo spin sequence to said mass, detecting two echoes and summing said echoes.

19. A method for measuring the perfusion of fluid into a mass, wherein the fluid passes a labelling position prior to perfusion into said mass, said method comprising the steps of:

magnetically labelling atoms in said fluid at said labelling position to produce labelled atoms;

allowing the labelled .atoms in said fluid to perfuse into said mass;

generating image information representing images with said labelled atoms for the mass containing said fluid;

generating control image information representing images without said labelled atoms for the mass containing said fluid;

generating relaxation image information representing images of said mass; and

processing said image information, control image information and relaxation image information to determine the quantity of said fluid per quantity of said mass per unit time which has perfused into said mass.

20. A method for measuring the perfusion of fluid into a mass without requiring the use of an exogenous tracer and wherein the fluid passes a labelling position prior to perfusion into said mass, said method comprising the steps of:

magnetically labelling atoms in said fluid at said labelling position to produce labelled atoms;

allowing the labelled atoms in said fluid to perfuse into said mass;

performing magnetic resonance measurements on said mass to generate intensity information for the mass containing said fluid; and

processing said intensity information to determine the quantity of said fluid per quantity of said mass per unit time which has perfused into said mass.

21. The method of claim 20, wherein the step of magnetically labelling atoms comprises the step of inverting spins associated with said atoms substantially continuously by adiabatic fast passage, and wherein the quantity of said fluid per quantity of said mass per unit time which has perfused into said mass (f) is related to a time constant T_1app representing the exponential decrease in the magnetization of said atoms per quantity of said mass by the equation:

##EQU14## where T₁ is a spin relaxation time for said atoms and λ

is a partition coefficient for water in said mass.