Interpenetrating-polymer network phase-transition gels

• US 5,403,893 A
• Filed: 11/10/1993
• Issued: 04/04/1995
• Est. Priority Date: 01/31/1991
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Tanaka, Toyoichi, Annaka, Masahiko, Kokufuta, Etsuo, Ilmain, Franck
• Primary Examiner(s): Michl, Paul R.
• Assistant Examiner(s): RAJGURU, UMAKANT K
• Application Number:
  US08/150,557
• Time in Patent Office: 510 Days
• Field of Search: 524/521, 524/522, 525/129, 525/218, 525/219, 523/105
• US Class Current: 525/218
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: C08L 101/00 Compositions of unspecified macromolecular compounds
• CPC Class Codes: Y10S 525/903 Interpenetrating network

Abstract

An interpenetrating gel and a method of forming an interpenetrating gel which undergoes a significantly large volume change in response to a physical or chemical stimululs is disclosed.

Claims

1. A composition of matter, comprising:

a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel capable of undergoing a reversible, continuous or discontinuous phase transition in response to a change in a specific stimulus applied to the gel.

2. The composition of claim 1, wherein said phase-transition is initiated by a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

3. The composition of claim 1, wherein said gel undergoes a discontinuous phase-transition collapse in response to the change in the specific stimulus.

4. A composition of matter, comprising:

an interpenetrating polymer network gel including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition in response to a change in a stimulus applied to the gel.

5. The composition of claim 4, wherein the at least one type of interaction is selected from the group consisting of van der Waals forces, hydrophobic interactions, hydrogen bonding, and ionic interactions.

6. The composition of claim 5, wherein the hydrogen bonding between said at least first and second polymers allows said polymers to form a polycomplex in which said polymers are aligned, polycomplex formation sufficient to induce said gel to undergo a discontinuous phase transition.

7. The composition of claim 4, wherein said change in stimulus is a change in temperature from a higher temperature to a lower temperature sufficient to cause the gel to undergo a phase-transition collapse in response to the change in temperature applied to the gel.

30. The composition of claim 4, wherein said change in stimulus is a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

31. The composition of claim 4, wherein said interpenetrating polymer network gel undergoes a discontinuous phase-transition collapse in response to the change in the specific stimulus.

8. A gel network capable of undergoing a continuous or discontinuous phase-transition in response to a change in a stimulus, the gel comprising:

an interpenetrating network of at least a first polymer and at least a second polymer, said polymers interpenetrating in a manner that results in an attractive interaction between the polymers of said network;

wherein said attractive interaction is sufficient to cause the gel network to undergo phase-transition in response to a change in stimulus applied to the gel.

9. The gel of claim 8, wherein said interpenetrating polymers are arranged to result in hydrogen bonding between said at least first and second polymers.

10. The gel of claim 9, wherein at least said first polymer is ionized.

11. The gel of claim 10, wherein ionization of at least one of said first or second polymers is directly related to the phase transition, such that a larger degree of ionization effects a discontinuous phase transition, and a smaller degree of ionization effects a continuous phase transition.

12. The gel of claim 11, wherein said at least first polymer is polyacrylic acid and said second polymer is polyacrylamide.

13. The gel of claim 12, wherein said first polymer is not ionized and said gel undergoes a continuous phase transition collapse in response to a decrease in temperature.

14. The gel of claim 12, wherein said first polymer is ionized to greater than about 3 percent and said gel undergoes a discontinuous phase transition collapse in response to a decrease in temperature.

15. The gel of claim 8, further comprising a chemical incorporated into the gel network, said chemical capable of being released from the gel network upon a phase-transition collapse in response to a change in stimulus applied to the gel network.

32. The gel of claim 9, wherein said hydrogen bonding interaction between the first and second polymers increases hydrophobicity of said polymer network.

16. A method for incorporating a material into a gel, comprising the steps of:

providing an interpenetrating polymer gel network including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition expansion in response to a change in a stimulus applied to the gel;

contacting the gel network with the material;

changing the specific stimulus such that the gel network undergoes phase-transition expansion, thereby incorporating the material into the gel network.

17. A method for releasing a material from a gel, comprising the steps of:

providing an interpenetrating polymer gel network including the material and at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition collapse in response to a change in a stimulus applied to the gel;

changing the specific stimulus such that the gel network undergoes a phase-transition collapse, thereby releasing the material from the gel.

18. In a polymer, wherein the improvement comprises:

at least a first polymer and at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a continuous or discontinuous phase-transition in response to a change in a stimulus applied to the gel.

19. The polymer of claim 18, wherein said phase-transition is initiated by a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

20. The polymer of claim 18, wherein the interaction is hydrogen bonding between said at least first and second polymers, said hydrogen bonding allowing said polymers to form a polycomplex in which said polymers are aligned, polycomplex formation sufficient to induce said gel to undergo a discontinuous phase transition in response to a change in stimulus applied to the gel.

21. The polymer of claim 20, wherein said change in stimulus is a change in temperature.

22. The polymer of claim 20, wherein said at least first polymer is polyacrylic acid and said second polymer is polyacrylamide.

23. A method of releasing a material in response to a change in stimulus comprising the steps of:

introducing the material into a medium;

coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition in response to the change in stimulus applied to the gel; and

changing the stimulus such that the gel coating expands and the material is released.

24. The method of claim 23, wherein the step of changing the stimulus comprises increasing pH.

25. The method of claim 23, wherein the step of introducing the material comprises introducing insulin.

26. The method of claim 24, wherein the step of changing the stimulus comprises exposing the coated medium to an intestine.

27. A method of absorbing a compound comprising the steps of:

providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound; and

contacting the gel with the compound such that the gel expands and absorbs the compound.

28. The method of claim 27, wherein the step of contacting the gel with the compound comprises contacting with cholesterol.

29. A method of separating a compound from a liquid medium comprising the steps of:

providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound;

contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.

33. A method of releasing a material in response to a change in stimulus comprising the steps of:

introducing the material into a medium;

coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition in response to the change in stimulus applied to the gel; and

changing the stimulus such that the gel coating expands and the material is released.

34. The method of claim 33, wherein the step of introducing the material comprises increasing pH.

35. The method of claim 33, wherein the step of introducing the material comprises introducing insulin.

36. The method of claim 34, wherein the step of changing the stimulus comprises exposing the coated medium to an intestine.

38. The method of claim 36, wherein the step of contacting the gel with the compound comprises contacting with cholesterol.

37. A method of absorbing a compound comprising the steps of:

providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase transition when contacted with the compound; and

contacting the gel with the compound such that the gel expands and absorbs the compound.

39. A method of separating a compound from a liquid medium comprising the steps of:

providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition when contacted with the compound;

contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.