Method for determining adequacy of dialysis based on urea concentration
First Claim
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1. A method for determining adequacy of dialysis of a patient, comprising:
- (a) providing an enzymatic urease-based sensor;
(b) using said sensor to determine a concentration of urea in dialysate from said dialysis;
(c) utilizing said urea concentration in said dialysate and selected physiological factors associated with the patient and with said dialysis to accurately determine a concentration of urea in arterial blood and to determine dialysis adequacy; and
(d) ceasing dialysis of said patient when said dialysis is adequate as determined in step (c).
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Abstract
A method for determining the adequacy of dialysis, using determination of urea concentration in the dialysate effluent with an enzymatic electrode incorporating a urease sensor, and conversion of this information to arterial urea nitrogen utilizing a "flow ratio" correction; and utilizing the arterial blood urea nitrogen derived from readings of an on-line monitoring sensor as an absolute quantity, and the urea reduction ratio as a relative quantity as a new end-point for dialysis adequacy.
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Citations
5 Claims
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1. A method for determining adequacy of dialysis of a patient, comprising:
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(a) providing an enzymatic urease-based sensor; (b) using said sensor to determine a concentration of urea in dialysate from said dialysis; (c) utilizing said urea concentration in said dialysate and selected physiological factors associated with the patient and with said dialysis to accurately determine a concentration of urea in arterial blood and to determine dialysis adequacy; and (d) ceasing dialysis of said patient when said dialysis is adequate as determined in step (c). - View Dependent Claims (2, 3)
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4. A method for determining adequacy of dialysis of a patient, comprising:
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(a) providing an enzymatic urease-based sensor; (b) using said sensor to determine a concentration of urea in dialysate from said dialysis; (c) utilizing said urea concentration in said dialysate and selected physiological factors associated with the patient and with said dialysis to accurately determine a concentration of urea in arterial blood and to determine dialysis adequacy; (d) calculating a urea reduction ratio; (e) utilizing the dialysis adequacy as an absolute quantity and the urea reduction ratio as a relative quantity as new end-points to determine when to cease dialysis; and (f) ceasing dialysis of said patient when said dialysis is adequate as determined in step (c) and step (e).
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5. A method for determining adequacy of dialysis of a patient, comprising:
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(a) providing an enzymatic urease-based sensor electrode; (b) using said electrode to determine a concentration of urea in dialysate from said dialysis; (c) utilizing said urea concentration in said dialysate to obtain an arterial urea concentration; (d) using said arterial urea concentration to obtain a profile of urea reduction; (e) using said profile to assess dialysis adequacy; (f) calculating a urea reduction ratio; (g) utilizing the dialysis adequacy as an absolute quantity and the urea reduction ratio as a relative quantity to determine when to cease dialysis; and (h) ceasing dialysis of said patient when said dialysis is adequate as determined in steps (e) and (g).
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Specification