Microencapsulation process and products therefrom
First Claim
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1. An emulsion-based method of microencapsulating an agent to form a microencapsulated product, comprising the steps of:
- a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion;
b) combining said dispersion with an effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and
c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction media.
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Abstract
A method of microencapsulating an agent to form a microencapsulated product, having the steps of dispersing an effective amount of the agent in a solvent containing a dissolved wall forming material to form a dispersion, combining the dispersion with an effective amount of a continuous process medium to form an emulsion that contains the process medium and microdroplets having the agent, the solvent and the wall forming material and adding rapidly the emulsion to an effective amount of an extraction medium to extract the solvent from the microdroplets to form the microencapsulated product.
495 Citations
73 Claims
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1. An emulsion-based method of microencapsulating an agent to form a microencapsulated product, comprising the steps of:
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a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction media. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A method of preparing a microencapsulated product having an encapsulating wall exhibiting high porosity, wherein the encapsulated agent is soluble in a continuous process medium, an extraction medium, or both media, comprising the steps of:
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a) dissolving or dispersing said agent in a solvent containing a dissolved wall forming material to form a dispersion;
the percentage of said agent to said wall forming material being greater than about 20 wt. %;b) combining said dispersion with an effective amount of said continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once alter step b) said emulsion to an effective amount of said extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium. - View Dependent Claims (61, 62, 63)
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64. A method of preparing a microencapsulated product having an encapsulating wall exhibiting low porosity, wherein the encapsulated agent is soluble in a continuous process medium, and extraction medium, or both media, comprising the steps of:
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a) dissolving or dispersing said agent in a solvent containing a dissolved wall forming material to form a dispersion;
the percentage of said agent to said wall forming material being less than about 20 wt. %;b) combining said dispersion with an effective amount of said continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once after step b) said emulsion to an effective amount of said extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part par 100 parts to about 25 parts per 100 parts in said extraction medium. - View Dependent Claims (65)
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66. A method of preparing a microencapsulated product having an encapsulating wall exhibiting high porosity, wherein the encapsulated agent is soluble in a continuous process medium, and extraction medium, or both media, comprising the steps of:
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a) dissolving or dispersing said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of said continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material, said continuous process medium having a solubility of from about 2% to about 25% in said solvent; and c) immediately after the formation of said emulsion, adding all at once after step b) said emulsion to an effective amount of said extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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67. A method of preparing a microencapsulated product having an encapsulating wall exhibiting low porosity, wherein the encapsulated agent is soluble in a continuous process medium, and extraction medium, or both media, comprising the steps of:
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a) dissolving or dispersing said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of said continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material, said continuous process medium having a solubility of less than about 2% in said solvent; and c) immediately after the formation of said emulsion, adding all at once after step b) said emulsion to an effective amount of said extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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68. A method of microencapsulating an agent from media in which said agent is soluble, to form a microencapsulated product, comprising the steps of:
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a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with and effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material, wherein said agent is soluble in said continuous process medium; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said agent is soluble in said extraction medium, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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69. A method of microencapsulating an agent, to form a microencapsulated product, comprising the steps of:
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a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with and effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material, wherein said agent is soluble in said continuous process medium; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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70. A method of microencapsulating an agent from media in which said agent is soluble, to form a microencapsulated product, comprising the steps of:
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a) dissolving dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with and effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said agent is soluble in said extraction medium, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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71. An emulsion-based method of microencapsulating an agent that is soluble in a continuous process medium, an extraction medium, or both media, to form a microencapsulated product comprising a central core of said agent surrounded by an outer membrane, comprising the steps of:
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a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of said continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of said extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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72. An emulsion based method of microencapsulating a water-soluble agent to form a microencapsulated product, comprising the steps of:
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a) dissolving or dispersing an effective amount of said water-soluble agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of an aqueous continuous process medium to form an emulsion that contains said aqueous process medium and microdroplets comprising said water-soluble agent, said solvent and said wall forming material; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an aqueous extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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73. An emulsion-based method of microencapsulating an agent that has a propensity to partition within minutes into the continuous phase of the emulsion to form a microencapsulated product, comprising the steps of:
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a) dissolving or dispersing an effective amount of said agent in a solvent containing a dissolved wall forming material to form a dispersion; b) combining said dispersion with an effective amount of a continuous process medium to form an emulsion that contains said process medium and microdroplets comprising said agent, said solvent and said wall forming material, wherein said agent has a propensity to partition within minutes into said continuous process medium; and c) immediately after the formation of said emulsion, adding all at once said emulsion to an effective amount of an extraction medium to extract said solvent from said microdroplets to form said microencapsulated product, wherein said solvent has a a solubility of from about 1 part per 100 parts to about 25 parts per 100 parts in said extraction medium.
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Specification