Fiber-optic probe for the measurement of fluid parameters
First Claim
1. An analyte sensor system for a fiber optic probe, the analyte sensor system comprisingtwo optical fibers comprising a first optical fiber and a second optical fiber, each optical fiber having two ends with an end of the first optical fiber having an optical fiber face opposed to an optical fiber face of an end of the second optical fiber, the two optical fiber faces spaced apart from each other,a cavity in the fiber optic probe between the two opposed optical fiber faces,an indicator matrix disposed in the cavity in a light path across the cavity between the two opposed optical fiber faces, the indicator matrix containing indicator molecules on a support, the indicator molecules for indicating a specific analyte,a membrane covering the indicator matrix in the cavity, the membrane disposed over the cavity on an exterior of the fiber optic probe, the membrane accessible by the specific analyte from the fiber optic probe'"'"'s exterior, the membrane selectively permeable to the specific analyte, andthe support comprising controlled pore glass particles.
6 Assignments
0 Petitions
Accused Products
Abstract
A fiber optic sensor suitable for measuring and monitoring fluid parameters, e.g. blood parameters such as carbon dioxide and oxygen partial pressure and hydrogen ion concentration ( pH ). Analyte sensitive chemistry in such probes includes molecules sensitive to responding to an analyte change in an optically detectable system. Methods of making analyte measuring chemistries including disposing an indicator complex in the path of light and casting over it films of permeable / semi- permeable polymer membranes capable of diffusion of gases and other analytes. A liquid control validation solution ) acts as a simulating standard for blood gas analysis. Liquid calibration solutions which mimic fluids such as blood to validate and test sensors for long term stability.
694 Citations
10 Claims
-
1. An analyte sensor system for a fiber optic probe, the analyte sensor system comprising
two optical fibers comprising a first optical fiber and a second optical fiber, each optical fiber having two ends with an end of the first optical fiber having an optical fiber face opposed to an optical fiber face of an end of the second optical fiber, the two optical fiber faces spaced apart from each other, a cavity in the fiber optic probe between the two opposed optical fiber faces, an indicator matrix disposed in the cavity in a light path across the cavity between the two opposed optical fiber faces, the indicator matrix containing indicator molecules on a support, the indicator molecules for indicating a specific analyte, a membrane covering the indicator matrix in the cavity, the membrane disposed over the cavity on an exterior of the fiber optic probe, the membrane accessible by the specific analyte from the fiber optic probe'"'"'s exterior, the membrane selectively permeable to the specific analyte, and the support comprising controlled pore glass particles.
-
9. An analyte sensor system for a fiber optic probe, the probe having at least one optical fiber, the analyte sensor comprising
two optical fibers comprising a first optical fiber with two ends and a second optical fiber with two ends, an end of the first optical fiber having an optical fiber face and spaced apart from an optical fiber face of an end of the second optical fiber, a cavity in the fiber optic probe between the two opposed optical fiber faces, an indicator matrix disposed in the cavity in a light path across the cavity between the two opposed optical fiber faces, the indicator matrix containing indicator molecules on a support, the indicator molecules for indicating a specific analyte, a membrane covering the indicator matrix in the cavity, the membrane disposed over the cavity on an exterior of the fiber optic probe, the membrane accessible by the specific analyte from the fiber optic probe'"'"'s exterior, the membrane selectively permeable to the specific analyte, and the support comprising a silica-gel-based porous particulate material with a particle size of about 10 microns.
Specification