Sample collection using catheter with expandable member

• US 5,409,012 A
• Filed: 12/30/1993
• Issued: 04/25/1995
• Est. Priority Date: 12/30/1993
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Corporation
• Inventors: Sahatjian, Ronald A.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US08/175,949
• Time in Patent Office: 481 Days
• Field of Search: 128/749, 128/752, 128/756, 128/757, 604/96, 604/101, 604/194
• US Class Current: 600/562
• CPC Class Codes: A61B 10/0275 with sample notch, e.g. on the side of inner stylet
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61M 2025/1072 having balloons with two or more compartments
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Taking a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a membrane with openings that communicate with space that communicates with a source of suction force. The catheter is positioned within the body. The sample is taken by exposing the membrane by placing it in proximity with a desired location so that the bodily sample is received by the membrane. The catheter is removed from the patient and the sample is collected outside the body.

Claims

1. A method for taking a liquid or tissue bodily sample from a desired location along a blood vessel of a patient and collecting said sample outside the body to facilitate treatment of the patient, comprising:

providing a sampling probe in the form of an elongate vascular catheter having a proximal portion that remains outside the body and a distal portion that can be located in the blood vessel during use, said distal portion including an expandable member that can be selectively expanded to larger diameter and contracted to smaller diameter,

said expandable member including a membrane thereon with openings that communicate with a source of suction force controllable from the proximal portion that remains outside the body,

positioning said expandable portion at a desired location within said blood vessel,

taking said sample by exposing said membrane by expanding said expandable portion to place said membrane in proximity with the wall of said blood vessel so that said liquid or tissue bodily sample is received by said membrane,

contracting said expandable portion to said smaller diameter,

removing said catheter from said patient, and

collecting said sample outside the body.

2. The method of claim 1 including drawing said sample to the surface of said membrane by suction forces.

3. The method of claim 2 comprising

drawing said sample with said suction forces through said membrane into a storage space.

4. The method of any one of claims 1, 2 or 3 comprising:

removing said sample by flushing force back out through said openings.

5. The method of any one of claims 1, 2 or 3 comprising:

expanding said expandable portion to contact said membrane with said vessel wall.

6. The method of any one of claims 1, 2 or 3 comprising:

moving said catheter axially while said membrane is in contact with said wall of said vessel to brush said membrane along said wall to collect said sample.

7. The method of any one of claims 1, 2 or 3 comprising:

providing a probe in the form of an angioplasty catheter having an expandable portion in the form of an inflatable balloon, said membrane being disposed over said balloon.

8. The method of claim 7 comprising:

positioning said expandable portion adjacent an occlusion in said vessel,

simultaneously expanding said occlusion, and

collecting said sample by expanding said expandable portion.

9. The method of claim 7 comprising:

performing angioplasty on an occluded region of said blood vessel,

positioning said expandable portion at said region at said region after said angioplasty, and

collecting said sample from said region.

13. The method of claim 1 or 11 or the kit of claim 10 wherein said membrane is a balloon wall including a series of lumens that communicate with openings on the outer surface of the balloon and with a lumen extending through the catheter to its proximal portion.

14. The method of claim 1 or 11 or the kit of claim 10 wherein said openings are size-selected to receive fluid and reject cell-size material.

15. The method of claim 1 or 11 or the kit of claim 10 wherein said openings are sized to receive cell samples.

16. The method of claim 1 or 10 further comprising receiving cell samples, and further comprising culturing said cells outside of the body and placing said cultured cells into the body.

17. The method of claim 16 further comprising genetically altering said cells before placing them in the body.

18. The method of claim 17 comprising placing said cells back in the body by placing them on said membrane outside the body, delivering said probe into the body, expanding said expandable portion to place said membrane in proximity with the wall of a blood vessel, and releasing said cells from said membrane.

10. A kit for treating a patient by collecting a liquid or tissue sample from a blood vessel of the patient that can be analyzed to determine physiological function, comprising:

a sampling probe in the form of an elongate vascular catheter having a proximal portion that remains outside the body and a distal portion that can be located in the blood vessel, said distal portion including an expandable member that can be selectively expanded to larger diameters and contracted to smaller diameter,

said expandable member including a membrane on at least a part of an outside surface of said expandable member, said membrane including openings that may receive said liquid or tissue sample and which communicate a suction device, controllable from proximal portions outside the body, for creating a suction force through said openings to draw bodily sample into said storage space, and

apparatus for facilitating collection and analysis of said sample outside the body to determine physiological function.

11. A method for taking a liquid or tissue bodily sample from deep within the body of a patient and collecting said sample outside the body to facilitate treatment of the patient, comprising:

providing a sampling probe in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body, said distal portion including an expandable member that can be selectively expanded to larger diameters and contracted to smaller diameter,

said expandable member including a membrane on at least a part of an outside surface of said expandable member, said membrane including openings that communicate with a suction device, controllable from proximal portions outside the body,

positioning said catheter within the body,

taking said liquid or tissue sample by expanding said expandable member to place said membrane in proximity to a desired location so that said bodily sample is received by said membrane,

removing said catheter from said patient, and

collecting said sample outside the body.

12. The method of claim 11 including taking said sample by applying suction forces through said membrane.