Sensors and methods for sensing
First Claim
1. A composition for measuring the concentration of an analyte in a medium comprising:
- a solid matrix material which is permeable to said analyte in said medium; and
an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium, wherein said monomeric components in enforced association are selected from the group consisting of intramolecular excited state complex forming molecules dispersed in a matrix material, intramolecular excited state complex forming molecules covalently attached, adsorbed or otherwise attached to the surface of a matrix material, intramolecular excited state complex forming molecules covalently attached to a matrix material, monomeric component aggregates covalently attached to a matrix material, monomeric component aggregates adsorbed to the surface of a matrix material, an inclusion complex comprising a supra-molecule, and ionically bound monomeric components.
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Accused Products
Abstract
A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one of which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
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Citations
31 Claims
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1. A composition for measuring the concentration of an analyte in a medium comprising:
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a solid matrix material which is permeable to said analyte in said medium; and an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium, wherein said monomeric components in enforced association are selected from the group consisting of intramolecular excited state complex forming molecules dispersed in a matrix material, intramolecular excited state complex forming molecules covalently attached, adsorbed or otherwise attached to the surface of a matrix material, intramolecular excited state complex forming molecules covalently attached to a matrix material, monomeric component aggregates covalently attached to a matrix material, monomeric component aggregates adsorbed to the surface of a matrix material, an inclusion complex comprising a supra-molecule, and ionically bound monomeric components. - View Dependent Claims (2, 3, 4, 24, 25)
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5. A composition for measuring the concentration of an analyte in a medium comprising:
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a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the detected second emitted signal has less than ten percent contribution due to monomer emission. - View Dependent Claims (6, 7, 8, 17, 18, 26, 28)
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9. A composition for measuring the concentration of an analyte in a medium comprising:
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a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium, wherein at least one of said monomeric components is covalently bonded to said solid matrix material. - View Dependent Claims (10, 11, 12, 27)
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13. A sensor for measuring the concentration of an analyte in a medium comprising:
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a sensing element comprising an analyte permeable matrix material and at least two different monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium. - View Dependent Claims (14, 15)
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16. A sensor for measuring the concentration of an analyte in a medium comprising:
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a sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the second emitted signal has less than ten percent contribution due to monomer emission; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
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19. A sensor for measuring the concentration of an analyte in a medium comprising:
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a sensing element comprising an analyte permeable matrix material and at least two monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal having a longer wavelength than said first emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium. - View Dependent Claims (20, 21, 29)
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22. A composition for measuring the concentration of an analyte in a medium comprising:
a tethered indicator component comprising at least two monomeric components, at least one of which is a monomeric indicator component capable of providing a first emitted signal or signals in response to being exposed to a first excitation signal, and at least one allyl moiety suitable for being covalently attached to a polysiloxane matrix material, said composition further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal and being dependent on the concentration of said analyte in said medium. - View Dependent Claims (23, 30, 31)
Specification