Method for producing pressure sensitive poly (N-vinyl lactam)

• US 5,409,966 A
• Filed: 10/15/1993
• Issued: 04/25/1995
• Est. Priority Date: 11/15/1991
• Status: Expired due to Fees

• Current Assignee: 3M Company
• Original Assignee: 3M Company
• Inventors: Asmus, Robert A., Duan, Daniel C., Benson, Olester Jr., Dietz, Timothy M., Uy, Rosa
• Primary Examiner(s): Berman, Susan W.
• Application Number:
  US08/137,665
• Time in Patent Office: 557 Days
• Field of Search: 522/167, 522/152, 522/79, 522/912, 523/111
• US Class Current: 522/152
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: C08L 2666/14 Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C08L 2666/28 Non-macromolecular organic substances
• CPC Class Codes: C08L 39/04 Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• CPC Class Codes: C09J 139/04 Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• CPC Class Codes: H01R 2201/12 for medicine and surgery
• CPC Class Codes: H01R 4/04 using electrically conductive adhesives
• CPC Class Codes: Y10S 522/912 Polymer derived from ethylenic monomers only
• CPC Class Codes: Y10S 526/931 Pressure sensitive adhesive

Abstract

A hydrophilic, pressure-sensitive adhesive composition prepared by irradiating solid poly(N-vinyl lactam) with ionizing radiation to crosslink the poly(N-vinyl lactam) and thereafter mixing the radiation-crosslinked poly(N-vinyl lactam) with essentially unirradiated plasticizer in an amount sufficient to form a cohesive, pressure-sensitive adhesive composition. The composition is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The composition is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The composition is also useful as a component in a skin covering for protecting mammalian skin Or mammalian skin openings with antimicrobial agents. A method of preparation of the composition is also disclosed.

Claims

1. A method of preparing a hydrophilic, pressure-sensitive adhesive composition comprising steps of:

(a) irradiating non-crosslinked poly(N-vinyl lactam) while in a solid form unmixed with plasticizer, with ionizing radiation to crosslink the solid poly(N-vinyl lactam), and

(b) mixing the solid, radiation-crosslinked poly(N-vinyl lactam) with an essentially unirradiated plasticizer in an amount sufficient to form a cohesive and pressure-sensitive adhesive composition.

2. The method according to claim 1, wherein the ionizing radiation comprises alpha, beta, gamma, electron-beam, or x-ray radiation.

3. The method according to claim 1, wherein the ionizing radiation is irradiated in at least one dose cumulatively comprising from about 25 kGys. to about 400 kGys.

4. The method according to claim 1, wherein the ionizing radiation is irradiated in at least one dose cumulatively comprising from about 25 to about 200 kGys.

5. The method according to claim 1, wherein the ionizing radiation is irradiated in at least one dose cumulatively comprising at least about 100 kGys.

6. The method according to claim 1, further comprising the step (c) of optionally mixing an electrolyte, an antimicrobial agent, or a pharmaceutical into the composition.

7. The method according to claim 6, further comprising the step (d) of mixing the radiation-crosslinked poly(N-vinyl lactam), the essentially unirradiated plasticizer, and optional electrolyte, antimicrobial agent, or pharmaceutical into a solvent;

the step (e) of casting the composition in solvent onto a substrate; and

the step (f) of evaporating solvent.