Cancer treatment and catheter for use in treatment
First Claim
1. Apparatus for isolation and treatment of a portion of the body comprising a first catheter adapted for percutaneous insertion into a vein or artery, comprising (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted;
- fenestrations in said plastic tube between said balloons to said main lumen;
second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood and (2) a second catheter for returning blood removed through said main lumen to the patient.
3 Assignments
0 Petitions
Accused Products
Abstract
Perfusing a high concentration of an agent to treat an organ, such as anti-cancer agents through a body organ containing a tumor, without their entering the body'"'"'s general circulation, removing them from the organ with effluent blood and transporting the contaminated blood to an extracorporeal circuit where the blood is treated to remove the contamination, and returning the treated blood to the body. The process prevents toxic levels of the agents from entering the body'"'"'s general circulation while delivering lethal doses of the agents to the tumor. There are described various apparatus for effecting the intra- and extracorporeal treatment of such contaminated blood.
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Citations
18 Claims
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1. Apparatus for isolation and treatment of a portion of the body comprising a first catheter adapted for percutaneous insertion into a vein or artery, comprising (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted;
- fenestrations in said plastic tube between said balloons to said main lumen;
second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood and (2) a second catheter for returning blood removed through said main lumen to the patient. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10)
- fenestrations in said plastic tube between said balloons to said main lumen;
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6. A catheter adapted for percutaneous insertion into a vein or artery, comprising:
- a plastic tube having a cranial end and a caudal end and defining a main lumen for outflowing blood, caudal and cranial balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted;
fenestrations in said plastic tube between said balloons to said main lumen, a second and third lumina within said plastic tube, said second lumina connecting to the balloon at said caudal end and said third lumina connecting to the cranial of balloon at the cranial end for effecting inflation or deflation of said balloons, the cranial end of said plastic tube is adapted to carry a smaller return catheter and said cranial end tapers to fit about said return catheter.
- a plastic tube having a cranial end and a caudal end and defining a main lumen for outflowing blood, caudal and cranial balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted;
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11. A kit for removing a treating agent from blood perfused through a body organ of a patient, comprising:
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a first catheter for isolating and removing the blood issuing from said body organ and containing said treating agent; a detoxification means for treating said blood so removed to remove said treating agent; and a second catheter for returning the blood so treated to said patient; said first catheter comprising; a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted;
fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood. - View Dependent Claims (12, 13, 14, 15)
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16. A process for removing a treating agent from blood perfused through a body organ of a patient comprising:
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isolating blood issuing from said body organ with a catheter; removing said blood containing said treating agent from said patient through said catheter; detoxifying the blood so removed to remove said treating agent; and returning the blood so detoxified to the patient; said catheter comprising; a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted;
fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to the one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood. - View Dependent Claims (17)
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18. A catheter adapted for percutaneous insertion into a vein or artery, comprising:
- a plastic tube having a cranial end and defining a main lumen for outflowing blood;
two balloons fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, said balloons when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted;
fenestrations in said plastic tube between said balloons to said main lumen;
second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons and a return lumen within said main lumen and extending to said cranial end, said cranial end sealing thereabout to prevent blood inflow from said cranial end into said main lumen, said return lumen discharging into the vein or artery beyond said cranial end.
- a plastic tube having a cranial end and defining a main lumen for outflowing blood;
Specification