Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections
First Claim
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1. Isolated DNA of a human papillomavirus (HPV), whereinsaid DNA is about 7,000 to about 8,000 base pairs;
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Abstract
The invention relates to papillomaviruses, particularly to DNA-HPVs isolated from the papillomaviruses IP5 and IP6, the restriction maps of which are presented in FIGS. 10 and 11, and also to probes containing these DNA-HPVs or fragments obtained from them. The invention relates, in addition, to "kits" containing distinct groups of probes, containing one of these DNA-HPVs or DNA-HPV fragments, as well as a procedure for the detection and identification of papillomaviruses which makes use of these different probes.
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8 Claims
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1. Isolated DNA of a human papillomavirus (HPV), wherein
said DNA is about 7,000 to about 8,000 base pairs; - and
said DNA is obtained from a virus selected from the group of papillomaviruses consisting of HPV-IP5 and HPV-IP6. - View Dependent Claims (2, 5, 6)
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3. An isolated DNA fragment, wherein said DNA fragment is obtained by treating HPV-IP5 DNA, or DNA complementary to HPV-IP5 DNA, with at least one restriction enzyme selected from the group consisting of EcoRI, PstI, HindII, PvuII, BamHI, HindIII, KpnI, AveI, and XbaI, and isolating said DNA fragment.
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4. An isolated DNA fragment, wherein said DNA fragment is obtained by treating HPV-IP6 DNA, or DNA complementary to HPV-IP6 DNA, with at least one restriction enzyme selected from the group consisting of EcoRI, PstI, HindII, PvuII, BamHI, HindIII, KpnI, AccI, BglII, SepI, EcoRV, and XbaI, and isolating said DNA fragment.
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7. The plasmid pSP65/IP5.
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8. The plasmid pSP64/IP6.
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