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Chemoprotective isothiocyanates

  • US 5,411,986 A
  • Filed: 03/12/1993
  • Issued: 05/02/1995
  • Est. Priority Date: 03/12/1993
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition comprising an active ingredient which is sulforaphane ((-)1-isothiocyanato-(4R)-(methylsulfinyl)butane) (CAS 4478-93-7) or an analogue thereof, said analogue being selected from the group consisting of:

  • 6-isothiocyanato-2-hexanone (GHP

         1105);

    exo-2-acetyl-6-isothiocyanatonorbornane (GHP

         1066);

    exo-2-isothiocyanato-6-methylsulfonylnorbornane(GHP

         1068);

    6-isothiocyanato-2-hexanol (GHP 1106;

    1-isothiocyanato-4-dimethylphosphonylbutane (GHP

         1078);

    exo-2-(1'"'"'-hydroxyethyl)-5-isothiocyanatonorbornane (GHP

         1075);

    exo-2-acetyl-5-isothiocyanatonorbornane (GHP

         1067);

    1-isothiocyanato-5-methylsulfonylpentane (GHP

         1003); and

    cis- or trans-3-(methylsulfonyl)cyclohexylmethylisothiocyanate (GHP 1079 or

         1080).

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