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Carbohydrate heterobifunctional cross-linking reagent

  • US 5,412,083 A
  • Filed: 04/16/1992
  • Issued: 05/02/1995
  • Est. Priority Date: 04/16/1992
  • Status: Expired due to Fees
First Claim
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1. A carbohydrate cross-linking reagent comprising a sequence of substituted glucosamine units in β

  • -1,4 linkage, said sequence having at the reducing end a tetrahydrofuran unit, said reagent having the formula ##STR20## wherein R1, R2 is H, (CH2 CH2 O)m H, (CH2 CH [CH3 ]O)m H, CH2 CO2 H, or CH2 CH2 CN, wherein m is an integer in the range of 1-10;

    n is greater than or equal to 2;

    R3 and R4 are acylating, alkylating, electrophilic or nucleophilic reactive substituents which are different from each other but mutually compatible neither R3 nor R4 is an acyl group, and at least one R4 is present; and

    R5 is an acyl group.

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