Non-invasive method for the in vivo determination of the oxygen saturation rate of arterial blood, and device for carrying out the method
First Claim
1. Method for determining the oxygen saturation rate of the arterial blood of a subject, in which the concentration of oxyhemoglobin or HbO2 is compared with the total concentration of hemoglobin, comprising the steps of providing first, second and third light sources emitting in respective wavelength bands including a near infrared wavelength band, a deep red wavelength band and a wavelength band therebetween, selectively directing light emitted from the respective light sources through an appropriate tissue region of the subject, acquiring representative signals of optical absorption through the tissue region, cyclicly exciting the light sources in succession and determining the frequency of the cyclic succession so as to be large as compared with the arterial pulsation frequency of the subject, and calculating concentrations of HbO2, Hb and HbCO to determine the oxygen saturation rate.
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Abstract
The apparatus comprises three laser diodes emitting at 660, 750 and 940 nm respectively, excited cyclically at the rate of a timer. The light emitted is channelled by three optical fibers to traverse a fully-vascularized tissue region of a subject along three virtually merged optical paths, and to terminate at an opto-electronic sensor, which generates overlapping signals representative of the molecular absorption. The pulsation of the arterial blood in the region induces variable components which are exclusively a function of the molecular absorptions due to oxyhemoglobin, deoxyhemoglobin and carboxyhemoglobin. The signals are switched by gates on three channels where the variable components are picked up and digitized, and then processed in a microprocessor to yield the oxygen saturation SaO2 and the carbon monoxide fixation of the hemoglobin.
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Citations
19 Claims
- 1. Method for determining the oxygen saturation rate of the arterial blood of a subject, in which the concentration of oxyhemoglobin or HbO2 is compared with the total concentration of hemoglobin, comprising the steps of providing first, second and third light sources emitting in respective wavelength bands including a near infrared wavelength band, a deep red wavelength band and a wavelength band therebetween, selectively directing light emitted from the respective light sources through an appropriate tissue region of the subject, acquiring representative signals of optical absorption through the tissue region, cyclicly exciting the light sources in succession and determining the frequency of the cyclic succession so as to be large as compared with the arterial pulsation frequency of the subject, and calculating concentrations of HbO2, Hb and HbCO to determine the oxygen saturation rate.
- 3. Method for determining the oxygen saturation rate of the arterial blood of a subject, by comparison of the concentration of oxyhemoglobin, or HbO2, with the concentration of total hemoglobin, including providing two light sources each emitting in a different wavelength band, one in near infrared and the second in deep red, directing light emitted by the light sources along two paths through an appropriate tissue region of the subject, providing an opto-electronic sensor for acquiring representative signals of optical absorption of the light, the representative signals comprising a variable component corresponding to absorption by pulsatile arterial blood, and a continuous component corresponding to absorption by the other tissues traversed, separating the variable component of each representative signal, calculating the respective concentrations of oxyhemoglobin, and deoxyhemoglobin or Hb, from the variable components, determining the oxygen saturation rate, wherein the improvement comprises the steps of providing a third light source emitting a third wavelength band between the aforesaid two bands and a corresponding third optical path associated with said third light source, exciting the three light sources in cyclic succession, selecting cyclic succession frequency so as to be large in comparison with the arterial pulsation frequency of the subject, whereby the representative signals overlap, and each representative signal is switched at the cyclic succession rate to a respective separate channel, and calculating concentrations of HbO2, Hb and HbCO to determine the oxygen saturation rate therefrom.
- 6. Apparatus for determining the oxygen saturation rate of the arterial blood of a subject, in which the concentration of oxyhemoglobin or HbO2 is compared with the total concentration of hemoglobin, comprising first, second and third light sources emitting light in respective wavelength bands including a near infrared wavelength band, a deep red wavelength band and a wavelength band therebetween, the respective light sources being directed at an appropriate tissue region of the subject, an opto-electronic sensing means acquiring representative signals of optical absorption of the admitted light through the tissue region, means for cyclicly exciting the light sources in succession, frequency of the cyclic succession being large as compared with the arterial pulsation frequency of the subject, and means for calculating concentrations of HbO2, Hb and HbCO to determine oxygen saturation rate.
- 13. Apparatus for determining the oxygen saturation rate of the arterial blood of a subject, comprising light sources emitting in respective wavelength bands, one of the wavelength bands being near infrared and another of the wavelength bands being deep red, opto-electronic sensing means for emitting respective signals responsive to optical absorption along respective optical paths through an appropriate tissue region of the subject, said signals including a variable component corresponding to absorptions by pulsatile arterial blood and a continuous component corresponding to absorption through other tissues traversed, means for separating the variable component of the respective absorption signals, calculating means for processing the variable components and determining the respective concentrations of oxyhemoglobin or HbO2, and deoxyhemoglobin or Hb, and also determining the oxygen saturation rate, further comprising a third light source emitting a wavelength band intermediate the first two wavelength bands, a third optical path between the third light source and the tissue region, the three optical paths terminating in said opto-electronic sensing means, means for exciting the three light sources in cyclic succession at a cyclic succession frequency which is large in comparison with pulse frequency of the subject whereby the representative signals overlap, means for switching each of the representative signals to a respective channel at the frequency of cyclic succession, said switching means comprising means for separating the variable component of the representative signal, said calculating means jointly processing the three variable components to identify HbO2, Hb and HbCO and determining the oxygen saturation rate therefrom.
Specification